Role of intestinal transporters in neonatal nutrition: Carbohydrates, proteins, lipids, minerals, and vitamins

Gaëlle Boudry, Elmer S. David, Véronique Douard, Iona M. Monteiro, Isabelle Le Huërou-Luron, Ronaldo P. Ferraris

Research output: Contribution to journalReview articlepeer-review

43 Scopus citations

Abstract

To support rapid growth and a high metabolic rate, infants require enormous amounts of nutrients. The small intestine must have the complete array of transporters that absorb the nutrients released from digested food. Failure of intestinal transporters to function properly often presents symptoms as "failure to thrive" because nutrients are not absorbed and as diarrhea because unabsorbed nutrients upset luminal osmolality or become substrates of intestinal bacteria. We enumerate the nutrients that constitute human milk and various infant milk formulas, explain their importance in neonatal nutrition, then describe for each nutrient the transporter(s) that absorbs it fromthe intestinal lumen into the enterocyte cytosol and fromthe cytosol to the portal blood. More than 100 membrane and cytosolic transporters are now thought to facilitate absorption of minerals and vitamins as well as products of digestion of the macronutrients carbohydrates, proteins, and lipids. We highlight research areas that should yield information needed to better understand the important role of these transporters during normal development.

Original languageEnglish (US)
Pages (from-to)380-401
Number of pages22
JournalJournal of pediatric gastroenterology and nutrition
Volume51
Issue number4
DOIs
StatePublished - Oct 2010

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Gastroenterology

Keywords

  • Absorption
  • Carrier
  • Metabolism
  • Neonatal
  • Perinatal
  • Small intestine

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