Role of macrophages in defective cell mediated immunity in lepromatous leprosy. I. Factor(s) from macrophages affecting protein synthesis and lymphocyte transformation

P. R. Salgame; T. J. Birdi; P. R. Mahadevan; N. H. Antia

Role of macrophages in defective cell mediated immunity in lepromatous leprosy. I. Factor(s) from macrophages affecting protein synthesis and lymphocyte transformation

P. R. Salgame, T. J. Birdi, P. R. Mahadevan, N. H. Antia

Research output: Contribution to journal › Article › peer-review

Abstract

Macrophages from lepromatous leprosy patients specifically show reduced protein synthesis in the presence of M. leprae. They also produce, as a result of interaction with M. leprae, factor(s) that reduce protein synthesis in normal macrophages as well as block lymphocyte transformation in normal leukocyte cultures in the presence of M. leprae as the antigen. These observations implicate a defective macrophage system in lepromatous leprosy patients.

Original language	English (US)
Pages (from-to)	172-177
Number of pages	6
Journal	International Journal of Leprosy
Volume	48
Issue number	2
State	Published - 1980
Externally published	Yes

All Science Journal Classification (ASJC) codes

Dermatology

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title = "Role of macrophages in defective cell mediated immunity in lepromatous leprosy. I. Factor(s) from macrophages affecting protein synthesis and lymphocyte transformation",

abstract = "Macrophages from lepromatous leprosy patients specifically show reduced protein synthesis in the presence of M. leprae. They also produce, as a result of interaction with M. leprae, factor(s) that reduce protein synthesis in normal macrophages as well as block lymphocyte transformation in normal leukocyte cultures in the presence of M. leprae as the antigen. These observations implicate a defective macrophage system in lepromatous leprosy patients.",

author = "Salgame, {P. R.} and Birdi, {T. J.} and Mahadevan, {P. R.} and Antia, {N. H.}",

year = "1980",

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pages = "172--177",

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AU - Birdi, T. J.

AU - Mahadevan, P. R.

AU - Antia, N. H.

PY - 1980

Y1 - 1980

N2 - Macrophages from lepromatous leprosy patients specifically show reduced protein synthesis in the presence of M. leprae. They also produce, as a result of interaction with M. leprae, factor(s) that reduce protein synthesis in normal macrophages as well as block lymphocyte transformation in normal leukocyte cultures in the presence of M. leprae as the antigen. These observations implicate a defective macrophage system in lepromatous leprosy patients.

AB - Macrophages from lepromatous leprosy patients specifically show reduced protein synthesis in the presence of M. leprae. They also produce, as a result of interaction with M. leprae, factor(s) that reduce protein synthesis in normal macrophages as well as block lymphocyte transformation in normal leukocyte cultures in the presence of M. leprae as the antigen. These observations implicate a defective macrophage system in lepromatous leprosy patients.

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ER -

Role of macrophages in defective cell mediated immunity in lepromatous leprosy. I. Factor(s) from macrophages affecting protein synthesis and lymphocyte transformation

Abstract

All Science Journal Classification (ASJC) codes

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