@inbook{ad5a5a05f1034cbba76077b7f7cc463f,
title = "Role of microglia in regulation of ethanol neurotoxic action",
abstract = "Exposure to alcohol, during development or adulthood, may result in damage to the nervous system, which underlies neurological and cognitive disruptions observed in patients with alcohol-related disorders, including fetal alcohol spectrum disorders (FASDs) and alcohol-use disorders (AUDs). Both clinical and preclinical evidence suggest microglia, the immune cells of the central nervous system, play a key role in modulating alcohol-induced neurotoxicity. Particularly, microglia are implicated in alcohol-induced neuroinflammation and in alcohol-induced increases in oxidative stress, which can lead to neuronal apoptosis. Recent studies also suggest a regenerative role for microglia in reestablishing homeostasis after alcohol exposure. These studies are summarized and reviewed in this chapter with emphasis on relevance to FASD and AUD.",
keywords = "Alcohol, Alcohol-use disorder, Apoptosis, Fetal alcohol spectrum disorder, Inflammation, Microglia, Neurotoxicity, Reactive oxygen species",
author = "Chastain, {Lucy G.} and Sarkar, {Dipak K.}",
note = "Funding Information: This work is partly supported by a National Institute of Health Grant R37AA08757 and R01AA016695. The authors would like to acknowledge Aaron DeLaRosa for his assistance in generating the figures for this paper.",
year = "2014",
doi = "10.1016/B978-0-12-801284-0.00004-X",
language = "English (US)",
series = "International Review of Neurobiology",
publisher = "Academic Press Inc.",
pages = "81--103",
booktitle = "International Review of Neurobiology",
address = "United States",
}