Role of nutraceuticals on Nrf2 and its implication in cancer prevention

Constance Lay Lay Saw, Ah-Ng Kong

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Nutraceuticals have recently become a hot topic for the commercial world and the biomedical community. It is postulated that nutraceuticals are relatively non-toxic food supplements with many health benefits including prevention of cancer. Many nutraceuticals are antioxidants by nature; isothiocyanates and polyphenols have been extensively researched in many laboratories including ours. This chapter will cover nutraceuticals from the mechanistic perspectives, and how they would interact with Nuclear factor (erythroid-derived 2)-like 2 (Nrf2), which is the master regulator of the antioxidant response to counteract oxidative stress. Nrf2 deficient (knockout; KO) mice lack response to some nutraceutical cancer chemopreventive agents suggesting the important role of Nrf2 in cancer prevention. Nrf2 is also shown to have protective function against inflammation, a pathological process that is implicated in many diseases including carcinogenesis. Scientific evidence on the role of nutraceuticals on Nrf2 in anti-oxidative stress coupled with anti-inflammatory will also be discussed in this chapter.

Original languageEnglish (US)
Title of host publicationNutraceuticals and Cancer
PublisherSpringer Netherlands
Pages61-75
Number of pages15
Volume9789400726307
ISBN (Electronic)9789400726307
ISBN (Print)9400726295, 9789400726291
DOIs
StatePublished - Dec 1 2012

Fingerprint

Dietary Supplements
Neoplasms
Oxidative Stress
Antioxidants
Isothiocyanates
Polyphenols
Insurance Benefits
Pathologic Processes
Knockout Mice
Carcinogenesis
Anti-Inflammatory Agents
Inflammation

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Keywords

  • Anti-inflammatory
  • Antioxidant response element
  • Carcinogenesis
  • Chemoprevention
  • Epigenetics
  • NF-κB
  • Nrf2
  • Nutraceuticals
  • Oxidative stress
  • Phase II detoxyfying/antioxidant genes

Cite this

Saw, C. L. L., & Kong, A-N. (2012). Role of nutraceuticals on Nrf2 and its implication in cancer prevention. In Nutraceuticals and Cancer (Vol. 9789400726307, pp. 61-75). Springer Netherlands. https://doi.org/10.1007/978-94-007-2630-7_4
Saw, Constance Lay Lay ; Kong, Ah-Ng. / Role of nutraceuticals on Nrf2 and its implication in cancer prevention. Nutraceuticals and Cancer. Vol. 9789400726307 Springer Netherlands, 2012. pp. 61-75
@inbook{7c6710a0a11b495fa156eac8150b6fe9,
title = "Role of nutraceuticals on Nrf2 and its implication in cancer prevention",
abstract = "Nutraceuticals have recently become a hot topic for the commercial world and the biomedical community. It is postulated that nutraceuticals are relatively non-toxic food supplements with many health benefits including prevention of cancer. Many nutraceuticals are antioxidants by nature; isothiocyanates and polyphenols have been extensively researched in many laboratories including ours. This chapter will cover nutraceuticals from the mechanistic perspectives, and how they would interact with Nuclear factor (erythroid-derived 2)-like 2 (Nrf2), which is the master regulator of the antioxidant response to counteract oxidative stress. Nrf2 deficient (knockout; KO) mice lack response to some nutraceutical cancer chemopreventive agents suggesting the important role of Nrf2 in cancer prevention. Nrf2 is also shown to have protective function against inflammation, a pathological process that is implicated in many diseases including carcinogenesis. Scientific evidence on the role of nutraceuticals on Nrf2 in anti-oxidative stress coupled with anti-inflammatory will also be discussed in this chapter.",
keywords = "Anti-inflammatory, Antioxidant response element, Carcinogenesis, Chemoprevention, Epigenetics, NF-κB, Nrf2, Nutraceuticals, Oxidative stress, Phase II detoxyfying/antioxidant genes",
author = "Saw, {Constance Lay Lay} and Ah-Ng Kong",
year = "2012",
month = "12",
day = "1",
doi = "10.1007/978-94-007-2630-7_4",
language = "English (US)",
isbn = "9400726295",
volume = "9789400726307",
pages = "61--75",
booktitle = "Nutraceuticals and Cancer",
publisher = "Springer Netherlands",
address = "Netherlands",

}

Saw, CLL & Kong, A-N 2012, Role of nutraceuticals on Nrf2 and its implication in cancer prevention. in Nutraceuticals and Cancer. vol. 9789400726307, Springer Netherlands, pp. 61-75. https://doi.org/10.1007/978-94-007-2630-7_4

Role of nutraceuticals on Nrf2 and its implication in cancer prevention. / Saw, Constance Lay Lay; Kong, Ah-Ng.

Nutraceuticals and Cancer. Vol. 9789400726307 Springer Netherlands, 2012. p. 61-75.

Research output: Chapter in Book/Report/Conference proceedingChapter

TY - CHAP

T1 - Role of nutraceuticals on Nrf2 and its implication in cancer prevention

AU - Saw, Constance Lay Lay

AU - Kong, Ah-Ng

PY - 2012/12/1

Y1 - 2012/12/1

N2 - Nutraceuticals have recently become a hot topic for the commercial world and the biomedical community. It is postulated that nutraceuticals are relatively non-toxic food supplements with many health benefits including prevention of cancer. Many nutraceuticals are antioxidants by nature; isothiocyanates and polyphenols have been extensively researched in many laboratories including ours. This chapter will cover nutraceuticals from the mechanistic perspectives, and how they would interact with Nuclear factor (erythroid-derived 2)-like 2 (Nrf2), which is the master regulator of the antioxidant response to counteract oxidative stress. Nrf2 deficient (knockout; KO) mice lack response to some nutraceutical cancer chemopreventive agents suggesting the important role of Nrf2 in cancer prevention. Nrf2 is also shown to have protective function against inflammation, a pathological process that is implicated in many diseases including carcinogenesis. Scientific evidence on the role of nutraceuticals on Nrf2 in anti-oxidative stress coupled with anti-inflammatory will also be discussed in this chapter.

AB - Nutraceuticals have recently become a hot topic for the commercial world and the biomedical community. It is postulated that nutraceuticals are relatively non-toxic food supplements with many health benefits including prevention of cancer. Many nutraceuticals are antioxidants by nature; isothiocyanates and polyphenols have been extensively researched in many laboratories including ours. This chapter will cover nutraceuticals from the mechanistic perspectives, and how they would interact with Nuclear factor (erythroid-derived 2)-like 2 (Nrf2), which is the master regulator of the antioxidant response to counteract oxidative stress. Nrf2 deficient (knockout; KO) mice lack response to some nutraceutical cancer chemopreventive agents suggesting the important role of Nrf2 in cancer prevention. Nrf2 is also shown to have protective function against inflammation, a pathological process that is implicated in many diseases including carcinogenesis. Scientific evidence on the role of nutraceuticals on Nrf2 in anti-oxidative stress coupled with anti-inflammatory will also be discussed in this chapter.

KW - Anti-inflammatory

KW - Antioxidant response element

KW - Carcinogenesis

KW - Chemoprevention

KW - Epigenetics

KW - NF-κB

KW - Nrf2

KW - Nutraceuticals

KW - Oxidative stress

KW - Phase II detoxyfying/antioxidant genes

UR - http://www.scopus.com/inward/record.url?scp=84931320080&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84931320080&partnerID=8YFLogxK

U2 - 10.1007/978-94-007-2630-7_4

DO - 10.1007/978-94-007-2630-7_4

M3 - Chapter

SN - 9400726295

SN - 9789400726291

VL - 9789400726307

SP - 61

EP - 75

BT - Nutraceuticals and Cancer

PB - Springer Netherlands

ER -

Saw CLL, Kong A-N. Role of nutraceuticals on Nrf2 and its implication in cancer prevention. In Nutraceuticals and Cancer. Vol. 9789400726307. Springer Netherlands. 2012. p. 61-75 https://doi.org/10.1007/978-94-007-2630-7_4