Role of vacuolating cytotoxin in gastritis due to Helicobacter pylori in gnotobiotic piglets

K. A. Eaton; T. L. Cover; M. K.R. Tummuru; M. J. Blaser; S. Krakowka

doi:10.1128/iai.65.8.3462-3464.1997

Role of vacuolating cytotoxin in gastritis due to Helicobacter pylori in gnotobiotic piglets

K. A. Eaton, T. L. Cover, M. K.R. Tummuru, M. J. Blaser, S. Krakowka

Research output: Contribution to journal › Article › peer-review

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Abstract

To investigate the role of the Helicobacter pylori cytotoxin in the pathogenesis of gastritis, gnotobiotic piglets were colonized with either toxigenic H. pylori or a nontoxigenic isogenic mutant. Only piglets given the toxigenic strain developed toxin-neutralizing antibodies (indicating that toxin is expressed in vivo), but there was no difference in bacterial colonization, epithelial vacuolation, or gastritis between the two groups of piglets.

Original language	English (US)
Pages (from-to)	3462-3464
Number of pages	3
Journal	Infection and immunity
Volume	65
Issue number	8
DOIs	https://doi.org/10.1128/iai.65.8.3462-3464.1997
State	Published - 1997
Externally published	Yes

All Science Journal Classification (ASJC) codes

Parasitology
Microbiology
Immunology
Infectious Diseases

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10.1128/iai.65.8.3462-3464.1997

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AU - Eaton, K. A.

AU - Cover, T. L.

AU - Tummuru, M. K.R.

AU - Blaser, M. J.

AU - Krakowka, S.

PY - 1997

Y1 - 1997

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AB - To investigate the role of the Helicobacter pylori cytotoxin in the pathogenesis of gastritis, gnotobiotic piglets were colonized with either toxigenic H. pylori or a nontoxigenic isogenic mutant. Only piglets given the toxigenic strain developed toxin-neutralizing antibodies (indicating that toxin is expressed in vivo), but there was no difference in bacterial colonization, epithelial vacuolation, or gastritis between the two groups of piglets.

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Role of vacuolating cytotoxin in gastritis due to Helicobacter pylori in gnotobiotic piglets

Abstract

All Science Journal Classification (ASJC) codes

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