Roles of Fe-S proteins: From cofactor synthesis to iron homeostasis to protein synthesis

Debkumar Pain, Andrew Dancis

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations

Abstract

Fe-S cluster assembly is an essential process for all cells. Impairment of Fe-S cluster assembly creates diseases in diverse and surprising ways. In one scenario, the loss of function of lipoic acid synthase, an enzyme with Fe-S cluster cofactor in mitochondria, impairs activity of various lipoamide-dependent enzymes with drastic consequences for metabolism. In a second scenario, the heme biosynthetic pathway in red cell precursors is specifically targeted, and iron homeostasis is perturbed, but lipoic acid synthesis is unaffected. In a third scenario, tRNA modifications arising from action of the cysteine desulfurase and/or Fe-S cluster proteins are lost, which may lead to impaired protein synthesis. These defects can then result in cancer, neurologic dysfunction or type 2 diabetes.

Original languageEnglish (US)
Pages (from-to)45-51
Number of pages7
JournalCurrent Opinion in Genetics and Development
Volume38
DOIs
StatePublished - Jun 1 2016

All Science Journal Classification (ASJC) codes

  • Genetics
  • Developmental Biology

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