Roles of TRAF molecules in B lymphocyte function

Ping Xie; Zachary J. Kraus; Laura L. Stunz; Gail A. Bishop

doi:10.1016/j.cytogfr.2008.04.002

Roles of TRAF molecules in B lymphocyte function

Ping Xie, Zachary J. Kraus, Laura L. Stunz, Gail A. Bishop

SAS-DLS-Ctr Collab Neurosci

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Tumor necrosis factor receptor associated factors (TRAFs) play a variety of interesting and important roles in the regulation of B lymphocyte function. They act both as cytoplasmic regulatory molecules, and as signal transducers for receptors involved in both innate and adaptive humoral immune responses. In this brief review, we highlight the current state of knowledge of the diverse roles of TRAF molecules in the functions of B lymphocytes.

Original language	English (US)
Pages (from-to)	199-207
Number of pages	9
Journal	Cytokine and Growth Factor Reviews
Volume	19
Issue number	3-4
DOIs	https://doi.org/10.1016/j.cytogfr.2008.04.002
State	Published - Jun 2008

All Science Journal Classification (ASJC) codes

Endocrinology, Diabetes and Metabolism
Immunology and Allergy
Immunology
Biochemistry, Genetics and Molecular Biology(all)

Keywords

B lymphocyte
CD40
Humoral immune responses
Signal transducers
TRAF

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title = "Roles of TRAF molecules in B lymphocyte function",

abstract = "Tumor necrosis factor receptor associated factors (TRAFs) play a variety of interesting and important roles in the regulation of B lymphocyte function. They act both as cytoplasmic regulatory molecules, and as signal transducers for receptors involved in both innate and adaptive humoral immune responses. In this brief review, we highlight the current state of knowledge of the diverse roles of TRAF molecules in the functions of B lymphocytes.",

keywords = "B lymphocyte, CD40, Humoral immune responses, Signal transducers, TRAF",

author = "Ping Xie and Kraus, {Zachary J.} and Stunz, {Laura L.} and Bishop, {Gail A.}",

note = "Funding Information: Ping Xie earned the PhD from the Hong Kong University of Science & Technology, followed by postdoctoral work at the University of Illinois at Chicago and the University of Iowa. She is currently an Assistant Research Scientist at the University of Iowa. She was a Special Fellow of the Leukemia & Lymphoma Society from 2002–2005. Her research is currently supported by a National Scientist Development Grant from the American Heart Association. ",

year = "2008",

month = jun,

doi = "10.1016/j.cytogfr.2008.04.002",

language = "English (US)",

volume = "19",

pages = "199--207",

journal = "Cytokine and Growth Factor Reviews",

issn = "1359-6101",

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T1 - Roles of TRAF molecules in B lymphocyte function

AU - Xie, Ping

AU - Kraus, Zachary J.

AU - Stunz, Laura L.

AU - Bishop, Gail A.

N1 - Funding Information: Ping Xie earned the PhD from the Hong Kong University of Science & Technology, followed by postdoctoral work at the University of Illinois at Chicago and the University of Iowa. She is currently an Assistant Research Scientist at the University of Iowa. She was a Special Fellow of the Leukemia & Lymphoma Society from 2002–2005. Her research is currently supported by a National Scientist Development Grant from the American Heart Association.

PY - 2008/6

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N2 - Tumor necrosis factor receptor associated factors (TRAFs) play a variety of interesting and important roles in the regulation of B lymphocyte function. They act both as cytoplasmic regulatory molecules, and as signal transducers for receptors involved in both innate and adaptive humoral immune responses. In this brief review, we highlight the current state of knowledge of the diverse roles of TRAF molecules in the functions of B lymphocytes.

AB - Tumor necrosis factor receptor associated factors (TRAFs) play a variety of interesting and important roles in the regulation of B lymphocyte function. They act both as cytoplasmic regulatory molecules, and as signal transducers for receptors involved in both innate and adaptive humoral immune responses. In this brief review, we highlight the current state of knowledge of the diverse roles of TRAF molecules in the functions of B lymphocytes.

KW - B lymphocyte

KW - CD40

KW - Humoral immune responses

KW - Signal transducers

KW - TRAF

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