Roles of TRAF molecules in B lymphocyte function

Ping Xie, Zachary J. Kraus, Laura L. Stunz, Gail A. Bishop

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Tumor necrosis factor receptor associated factors (TRAFs) play a variety of interesting and important roles in the regulation of B lymphocyte function. They act both as cytoplasmic regulatory molecules, and as signal transducers for receptors involved in both innate and adaptive humoral immune responses. In this brief review, we highlight the current state of knowledge of the diverse roles of TRAF molecules in the functions of B lymphocytes.

Original languageEnglish (US)
Pages (from-to)199-207
Number of pages9
JournalCytokine and Growth Factor Reviews
Volume19
Issue number3-4
DOIs
StatePublished - Jun 2008

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

Keywords

  • B lymphocyte
  • CD40
  • Humoral immune responses
  • Signal transducers
  • TRAF

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