RUNX2 is overexpressed in melanoma cells and mediates their migration and invasion

Rajeev K. Boregowda, Oyenike O. Olabisi, Walid Abushahba, Byeong Seon Jeong, Keneshia K. Haenssen, Wenjin Chen, Marina Chekmareva, Ahmed Lasfar, David J. Foran, James S. Goydos, Karine A. Cohen-Solal

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

In the present study, we investigated the role of the transcription factor RUNX2 in melanomagenesis. We demonstrated that the expression of transcriptionally active RUNX2 was increased in melanoma cell lines as compared with human melanocytes. Using a melanoma tissue microarray, we showed that RUNX2 levels were higher in melanoma cells as compared with nevic melanocytes. RUNX2 knockdown in melanoma cell lines significantly decreased Focal Adhesion Kinase expression, and inhibited their cell growth, migration and invasion ability. Finally, the pro-hormone cholecalciferol reduced RUNX2 transcriptional activity and decreased migration of melanoma cells, further suggesting a role of RUNX2 in melanoma cell migration.

Original languageEnglish (US)
Pages (from-to)61-70
Number of pages10
JournalCancer Letters
Volume348
Issue number1-2
DOIs
StatePublished - 2014

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Keywords

  • Cholecalciferol (Vitamin D3)
  • FAK
  • Melanoma
  • Migration
  • RUNX2
  • Transcription factor

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