Ruthenium(II)-catalyzed C-H arylation of N,N-dialkyl thiobenzamides with boronic acids by sulfur coordination in 2-MeTHF

Jin Zhang, Ying Liu, Qiangqiang Jia, Yue Wang, Yangmin Ma, Michal Szostak

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

We report ruthenium(II)-catalyzed ortho-C-H arylation of N,N-dialkylthiobenzamides with boronic acids. The method employs [RuCl2(p-cym)]2 in the presence of Cu(OTf)2 and Ag2O oxidant. The reaction represents the first example of Ru-catalyzed C-H arylation directed by sulfur-containing groups and a rare example of C-H arylation directed by the versatile thiobenzamide moiety. As a further advantage, the method is performed in sustainable and eco-friendly 2-MeTHF as a solvent.

Original languageEnglish (US)
Pages (from-to)6884-6890
Number of pages7
JournalOrganic letters
Volume22
Issue number17
DOIs
StatePublished - Sep 4 2020

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Ruthenium(II)-catalyzed C-H arylation of N,N-dialkyl thiobenzamides with boronic acids by sulfur coordination in 2-MeTHF'. Together they form a unique fingerprint.

Cite this