Scale-up strategy for continuous powder blending process

Yijie Gao, Fernando J. Muzzio, Marianthi G. Ierapetritou

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Continuous powder mixing has attracted a lot of interest within the pharmaceutical industry. Much work has been done recently that targets the characterization of continuous powder mixing. In this paper, a quantitative scaling up strategy is introduced that allows the transition from lab to industrial scale. The proposed methodology is based on the variance spectrum analysis, and the residence time distribution, which are key indexes in capturing scale-up of the batch-like mixing, and scale-up of the axial mixing and motion, respectively. Our simulation results are used as preliminary guidance for scaling up different powder mixing cases.

Original languageEnglish (US)
Pages (from-to)55-69
Number of pages15
JournalPowder Technology
Volume235
DOIs
StatePublished - Feb 2013

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)

Keywords

  • DEM
  • Periodic section modeling
  • Powder blending
  • RTD
  • Sample size
  • Scale-up

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