Schiff base formation in the development of a spectrophotometric assay for sulfonamides

John L. Colaizzi; John W. Boenigk; Alfred N. Martin; Adelbert M. Knevel

doi:10.1002/jps.2600540415

Schiff base formation in the development of a spectrophotometric assay for sulfonamides

John L. Colaizzi, John W. Boenigk, Alfred N. Martin, Adelbert M. Knevel

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The reaction between aromatic amines and aromatic aldehydes was investigated as the basis of a spectrophotometric assay for sulfonamides. Those properties of the equilibrium reaction which affect the absorptimetric properties of the system were studied to evaluate the method. The effects of pH, ionic strength, concentration of aldehyde, solvent system, and temperature were determined. The method was applied to the determination of sulfanilamide, sulfadimethoxine, and succinylsulfathiazole, and comparative analyses were performed with the method of Bratton and Marshall. The low absorbance method of precision spectrophotometry was employed in the determination of microgram quantities of sulfanilamide.

Original language	English (US)
Pages (from-to)	564-568
Number of pages	5
Journal	Journal of Pharmaceutical Sciences
Volume	54
Issue number	4
DOIs	https://doi.org/10.1002/jps.2600540415
State	Published - Apr 1965
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pharmaceutical Science

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10.1002/jps.2600540415

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title = "Schiff base formation in the development of a spectrophotometric assay for sulfonamides",

abstract = "The reaction between aromatic amines and aromatic aldehydes was investigated as the basis of a spectrophotometric assay for sulfonamides. Those properties of the equilibrium reaction which affect the absorptimetric properties of the system were studied to evaluate the method. The effects of pH, ionic strength, concentration of aldehyde, solvent system, and temperature were determined. The method was applied to the determination of sulfanilamide, sulfadimethoxine, and succinylsulfathiazole, and comparative analyses were performed with the method of Bratton and Marshall. The low absorbance method of precision spectrophotometry was employed in the determination of microgram quantities of sulfanilamide.",

author = "Colaizzi, {John L.} and Boenigk, {John W.} and Martin, {Alfred N.} and Knevel, {Adelbert M.}",

year = "1965",

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T1 - Schiff base formation in the development of a spectrophotometric assay for sulfonamides

AU - Colaizzi, John L.

AU - Boenigk, John W.

AU - Martin, Alfred N.

AU - Knevel, Adelbert M.

PY - 1965/4

Y1 - 1965/4

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AB - The reaction between aromatic amines and aromatic aldehydes was investigated as the basis of a spectrophotometric assay for sulfonamides. Those properties of the equilibrium reaction which affect the absorptimetric properties of the system were studied to evaluate the method. The effects of pH, ionic strength, concentration of aldehyde, solvent system, and temperature were determined. The method was applied to the determination of sulfanilamide, sulfadimethoxine, and succinylsulfathiazole, and comparative analyses were performed with the method of Bratton and Marshall. The low absorbance method of precision spectrophotometry was employed in the determination of microgram quantities of sulfanilamide.

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