Abstract
Peripheral nerve injury is followed by a wave of Schwann cell proliferation in the distal nerve stumps. To resolve the role of Schwann cell proliferation during functional recovery of the injured nerves, we used a mouse model in which injury-induced Schwann cell mitotic response is ablated via targeted disruption of cyclin D1. In the absence of distal Schwann cell proliferation, axonal regeneration and myelination occur normally in the mutant mice and functional recovery of injured nerves is achieved. This is enabled by pre-existing Schwann cells in the distal stump that persist but do not divide. On the other hand, in the wild type littermates, newly generated Schwann cells of injured nerves are culled by apoptosis. As a result, distal Schwann cell numbers in wild type and cyclin D1 null mice converge to equivalence in regenerated nerves. Therefore, distal Schwann cell proliferation is not required for functional recovery of injured nerves.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 80-88 |
| Number of pages | 9 |
| Journal | Molecular and Cellular Neuroscience |
| Volume | 38 |
| Issue number | 1 |
| DOIs | |
| State | Published - May 1 2008 |
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All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cellular and Molecular Neuroscience
- Cell Biology
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Schwann cell proliferation during Wallerian degeneration is not necessary for regeneration and remyelination of the peripheral nerves : Axon-dependent removal of newly generated Schwann cells by apoptosis. / Yang, David P.; Zhang, Dan P.; Mak, Kimberley S.; Bonder, Daniel E.; Pomeroy, Scott L.; Kim, Haesun.
In: Molecular and Cellular Neuroscience, Vol. 38, No. 1, 01.05.2008, p. 80-88.Research output: Contribution to journal › Article
TY - JOUR
T1 - Schwann cell proliferation during Wallerian degeneration is not necessary for regeneration and remyelination of the peripheral nerves
T2 - Axon-dependent removal of newly generated Schwann cells by apoptosis
AU - Yang, David P.
AU - Zhang, Dan P.
AU - Mak, Kimberley S.
AU - Bonder, Daniel E.
AU - Pomeroy, Scott L.
AU - Kim, Haesun
PY - 2008/5/1
Y1 - 2008/5/1
N2 - Peripheral nerve injury is followed by a wave of Schwann cell proliferation in the distal nerve stumps. To resolve the role of Schwann cell proliferation during functional recovery of the injured nerves, we used a mouse model in which injury-induced Schwann cell mitotic response is ablated via targeted disruption of cyclin D1. In the absence of distal Schwann cell proliferation, axonal regeneration and myelination occur normally in the mutant mice and functional recovery of injured nerves is achieved. This is enabled by pre-existing Schwann cells in the distal stump that persist but do not divide. On the other hand, in the wild type littermates, newly generated Schwann cells of injured nerves are culled by apoptosis. As a result, distal Schwann cell numbers in wild type and cyclin D1 null mice converge to equivalence in regenerated nerves. Therefore, distal Schwann cell proliferation is not required for functional recovery of injured nerves.
AB - Peripheral nerve injury is followed by a wave of Schwann cell proliferation in the distal nerve stumps. To resolve the role of Schwann cell proliferation during functional recovery of the injured nerves, we used a mouse model in which injury-induced Schwann cell mitotic response is ablated via targeted disruption of cyclin D1. In the absence of distal Schwann cell proliferation, axonal regeneration and myelination occur normally in the mutant mice and functional recovery of injured nerves is achieved. This is enabled by pre-existing Schwann cells in the distal stump that persist but do not divide. On the other hand, in the wild type littermates, newly generated Schwann cells of injured nerves are culled by apoptosis. As a result, distal Schwann cell numbers in wild type and cyclin D1 null mice converge to equivalence in regenerated nerves. Therefore, distal Schwann cell proliferation is not required for functional recovery of injured nerves.
UR - http://www.scopus.com/inward/record.url?scp=43049098832&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=43049098832&partnerID=8YFLogxK
U2 - 10.1016/j.mcn.2008.01.017
DO - 10.1016/j.mcn.2008.01.017
M3 - Article
C2 - 18374600
AN - SCOPUS:43049098832
VL - 38
SP - 80
EP - 88
JO - Molecular and Cellular Neurosciences
JF - Molecular and Cellular Neurosciences
SN - 1044-7431
IS - 1
ER -