Searching for human oncoviruses: Histories, challenges, and opportunities

Jian Cao, Dawei Li

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Oncoviruses contribute significantly to cancer burden. A century of tumor virological studies have led to the discovery of seven well-accepted human oncoviruses, cumulatively responsible for approximately 15% of human cancer cases. Virus-caused cancers are largely preventable through vaccination. Identifying additional oncoviruses and virus-caused tumors will advance cancer prevention and precision medicine, benefiting affected individuals, and society as a whole. The historic success of finding human oncoviruses has provided a unique lesson for directing new research efforts in the post-sequencing era. Combing the experiences from these pioneer studies with emerging high-throughput techniques will certainly accelerate new discovery and advance our knowledge of the remaining human oncoviruses.

Original languageEnglish (US)
Pages (from-to)4897-4906
Number of pages10
JournalJournal of Cellular Biochemistry
Issue number6
StatePublished - Jun 2018
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology


  • clonal amplification
  • clonal integration
  • oncovirus
  • tumor virus
  • whole-genome sequencing (WGS)

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