Seasonal Variation in Flares of Inflammatory Bowel Disease

James D. Lewis, Faten N. Aberra, Gary R. Lichtenstein, Warren B. Bilker, Colleen Brensinger, Brian Strom

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Background & Aims: Previous research has yielded conflicting data as to whether the natural history of inflammatory bowel disease follows a seasonal pattern. The purpose of this study was to determine whether relapse of inflammatory bowel disease follows a seasonal pattern either across a cohort of patients or within individual patients. Methods: We used 1988 to 1997 data from the General Practice Research Database to conduct a retrospective cohort study of 1587 patients with Crohn's disease (mean age at start of follow-up, 41 ± 17 years) and 2773 patients with ulcerative colitis (mean age at start of follow-up, 48 ± 16 years). Flares of disease were identified by receipt of a new prescription for either corticosteroids or 5-ASA medications following an interval of at least 4 months without prescriptions for either class of medication. Logistic regression was used to adjust the association of season of the year and flare of disease for potential confounding variables. Results: There was no association between season of the year and flare of Crohn's disease (P = 0.66). Season of the year was only weakly associated with flares of ulcerative colitis (P = 0.02). Compared with winter, spring had very slightly higher rates of flares (OR = 1.13, 95% CI: 1.05-1.23). We did not observe seasonal patterns within individual patients experiencing multiple flares (P > 0.05 for Crohn's disease and ulcerative colitis). Conclusions: Although we observed a slight increase in exacerbations of ulcerative colitis in the spring, in general, these data do not support an association between season of the year and flares.

Original languageEnglish (US)
Pages (from-to)665-673
Number of pages9
JournalGastroenterology
Volume126
Issue number3
DOIs
StatePublished - Jan 1 2004

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Inflammatory Bowel Diseases
Ulcerative Colitis
Crohn Disease
Prescriptions
Confounding Factors (Epidemiology)
Research
General Practice
Adrenal Cortex Hormones
Cohort Studies
Retrospective Studies
Logistic Models
Databases
Recurrence

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Lewis, J. D., Aberra, F. N., Lichtenstein, G. R., Bilker, W. B., Brensinger, C., & Strom, B. (2004). Seasonal Variation in Flares of Inflammatory Bowel Disease. Gastroenterology, 126(3), 665-673. https://doi.org/10.1053/j.gastro.2003.12.003
Lewis, James D. ; Aberra, Faten N. ; Lichtenstein, Gary R. ; Bilker, Warren B. ; Brensinger, Colleen ; Strom, Brian. / Seasonal Variation in Flares of Inflammatory Bowel Disease. In: Gastroenterology. 2004 ; Vol. 126, No. 3. pp. 665-673.
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Lewis, JD, Aberra, FN, Lichtenstein, GR, Bilker, WB, Brensinger, C & Strom, B 2004, 'Seasonal Variation in Flares of Inflammatory Bowel Disease', Gastroenterology, vol. 126, no. 3, pp. 665-673. https://doi.org/10.1053/j.gastro.2003.12.003

Seasonal Variation in Flares of Inflammatory Bowel Disease. / Lewis, James D.; Aberra, Faten N.; Lichtenstein, Gary R.; Bilker, Warren B.; Brensinger, Colleen; Strom, Brian.

In: Gastroenterology, Vol. 126, No. 3, 01.01.2004, p. 665-673.

Research output: Contribution to journalArticle

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Lewis JD, Aberra FN, Lichtenstein GR, Bilker WB, Brensinger C, Strom B. Seasonal Variation in Flares of Inflammatory Bowel Disease. Gastroenterology. 2004 Jan 1;126(3):665-673. https://doi.org/10.1053/j.gastro.2003.12.003