SECIS binding proteins and eukaryotic selenoprotein synthesis

Donna M. Driscoll, Paul R. Copeland

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

In eukaryotes, the biosynthesis of selenoproteins involves a novel translational mechanism that recodes UGA as selenocysteine (See). The decision to incorporate Sec rather than terminate protein synthesis involves at least two RNA-binding proteins that interact specifically with a conserved motif within the 3' untranslated region (3' UTR) of the selenoprotein mRNA. The structures, functions, and interactions of these two proteins, SECIS Binding Protein 2 (SBP2) and ribosomal protein L30 (L30), are considered in detail in this chapter.

Original languageEnglish (US)
Title of host publicationSelenium
Subtitle of host publicationIts Molecular Biology and Role in Human Health, Second Edition
PublisherSpringer US
Pages63-72
Number of pages10
ISBN (Electronic)9780387338279
ISBN (Print)0387338268, 9780387338262
DOIs
StatePublished - 2006

All Science Journal Classification (ASJC) codes

  • General Medicine

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