TY - JOUR
T1 - Seeing the pdb
AU - Richardson, Jane S.
AU - Richardson, David C.
AU - Goodsell, David S.
N1 - Funding Information:
and visualizations have been almost entirely supported by National Institutes of Health General Medical Sciences, from 30 years of R01 GM15000 (D. C. R.) to our current P01-GM063210 Project IV (J. S. R.) and R35-GM131883 (D. C. R.). Goodsell’s visualization work is supported by grant GM120604 from the National Institutes of Health and the RCSB Protein Data Bank (National Science Foundation DBI-1832184, National Institutes of Health GM133198, and US Department of Energy DE-SC0019749). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Publisher Copyright:
© 2021 THE AUTHORS.
PY - 2021
Y1 - 2021
N2 - Ever since the first structures of proteins were determined in the 1960s, structural biologists have required methods to visualize biomolecular structures, both as an essential tool for their research and also to promote 3D comprehension of structural results by a wide audience of researchers, students, and the general public. In this review to celebrate the 50th anniversary of the Protein Data Bank, we present our own experiences in developing and applying methods of visualization and analysis to the ever-expanding archive of protein and nucleic acid structures in the worldwide Protein Data Bank. Across that timespan, Jane and David Richardson have concentrated on the organization inside and between the macromolecules, with ribbons to show the overall backbone "fold"and contact dots to show how the all-atom details fit together locally. David Goodsell has explored surface-based representations to present and explore biological subjects that range from molecules to cells. This review concludes with some ideas about the current challenges being addressed by the field of biomolecular visualization.
AB - Ever since the first structures of proteins were determined in the 1960s, structural biologists have required methods to visualize biomolecular structures, both as an essential tool for their research and also to promote 3D comprehension of structural results by a wide audience of researchers, students, and the general public. In this review to celebrate the 50th anniversary of the Protein Data Bank, we present our own experiences in developing and applying methods of visualization and analysis to the ever-expanding archive of protein and nucleic acid structures in the worldwide Protein Data Bank. Across that timespan, Jane and David Richardson have concentrated on the organization inside and between the macromolecules, with ribbons to show the overall backbone "fold"and contact dots to show how the all-atom details fit together locally. David Goodsell has explored surface-based representations to present and explore biological subjects that range from molecules to cells. This review concludes with some ideas about the current challenges being addressed by the field of biomolecular visualization.
UR - http://www.scopus.com/inward/record.url?scp=85106479171&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85106479171&partnerID=8YFLogxK
U2 - 10.1016/J.JBC.2021.100742
DO - 10.1016/J.JBC.2021.100742
M3 - Review article
C2 - 33957126
AN - SCOPUS:85106479171
SN - 0021-9258
VL - 296
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
M1 - 100742
ER -