Selection of topically applied non-steroidal anti-inflammatory drugs for oral cancer chemoprevention

Sandeep Sood, Steven J. Shiff, Chung S. Yang, Xiaoxin Chen

Research output: Contribution to journalReview article

24 Scopus citations

Abstract

Topical delivery of non-steroidal anti-inflammatory drugs through the oral mucosa has been used for oral cancer chemoprevention. Local permeation of these agents has been one of the major concerns. Here we propose an approach to predict the permeability of topically applied agents for oral cancer chemoprevention. In theory, the total flux through the oral mucosa (J max) can be estimated by adding the transcellular flux (J TC) and the paracellular flux (JPC). To target the Cox-2 enzyme in oral epithelial cells, it is desirable to maximize the theoretical activity index, the ratio of JTC and IC50 of a Cox-2 inhibitor (JTC/IC50-Cox-2). Among the 12 commonly used NSAIDs, celecoxib, nimesulide and ibuprofen had the highest values and may be the agents of choice to target Cox-2 in oral epithelial cells through topical application. Based on these calculations, a long-term chemopreventive experiment using celecoxib (3% or 6%) through topical application was performed in a DMBA induced hamster oral cancer model. Both 3% and 6% reduced the incidence of squamous cell carcinoma at the post-initiation stage.

Original languageEnglish (US)
Pages (from-to)562-567
Number of pages6
JournalOral Oncology
Volume41
Issue number6
DOIs
StatePublished - Jul 1 2005

All Science Journal Classification (ASJC) codes

  • Oral Surgery
  • Oncology
  • Cancer Research

Keywords

  • NSAIDs
  • Oral cancer

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