Selective entorhinal and nonselective cortical-hippocampal region lesions, but not selective hippocampal lesions, disrupt learned irrelevance in rabbit eyeblink conditioning

M. Todd Allen, Lori Chelius, Mark A. Gluck

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Prior experiments, as well as computational models, have implicated the hippocampal region in mediating the influence of nonreinforced stimulus preexposure on subsequent learning. Learned irrelevance (LIRR) is a preexposure task in which uncorrelated preexposures to the conditioned stimulus (CS) and the unconditioned stimulus (US) produce a retardation of subsequent CS-US conditioning. In the work presented here, we report the results of tests of LIRR in eyeblink conditioning in rabbits with sham lesions, nonselective cortical-hippocampal region lesions, selective hippocampal lesions, and selective entorhinal lesions. Sham-lesioned rabbits that had been preexposed to the CS and the US exhibited slower acquisition of conditioned responses, as compared with context-preexposed controls. Nonselective cortical-hippocampal region lesions disrupted LIRR, whereas selective hippocampal lesions had no detrimental effect on LIRR. Selective entorhinal lesions disrupted LIRR. These findings fit other recent empirical findings and theoretical predictions that some classical conditioning tasks previously thought to depend on the hippocampus depend, rather, on the entorhinal cortex.

Original languageEnglish (US)
Pages (from-to)214-226
Number of pages13
JournalCognitive, Affective and Behavioral Neuroscience
Volume2
Issue number3
DOIs
StatePublished - Sep 2002

All Science Journal Classification (ASJC) codes

  • Cognitive Neuroscience
  • Behavioral Neuroscience

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