Selective increase in pericentral oxygen gradient in perfused rat liver following ethanol treatment

Sungchul Ji; John J. Lemasters; Vickie Christenson; Ronald G. Thurman

doi:10.1016/0091-3057(83)90214-9

Selective increase in pericentral oxygen gradient in perfused rat liver following ethanol treatment

Sungchul Ji, John J. Lemasters, Vickie Christenson, Ronald G. Thurman

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The oxygen gradient across the liver lobule was measured in isolated, hemoglobin-free perfused livers from control and ethanol-treated rats using micro-light guides and miniature oxygen electrodes. Both techniques yielded similar values for the lobular, periportal and pericentral oxygen gradients. Oxygen uptake increased 33% in livers from rats treated with ethanol for 4 to 6 weeks. In addition, the pericentral oxygen gradient increased by 100%, but the periportal gradient was unchanged. These observations suggest that chronic ethanol treatment may increase the rate of cellular respiration in ethanol-induced inhibition of glycolysis which predominates in pericentral hepatocytes.

Original language	English (US)
Pages (from-to)	439-442
Number of pages	4
Journal	Pharmacology, Biochemistry and Behavior
Volume	18
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1016/0091-3057(83)90214-9
State	Published - 1983
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Toxicology
Pharmacology
Clinical Biochemistry
Biological Psychiatry
Behavioral Neuroscience

Keywords

Ethanol
Liver
Oxygen gradient
Rat

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10.1016/0091-3057(83)90214-9

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@article{d5ffb55d58a44176972450b5650aa20d,

title = "Selective increase in pericentral oxygen gradient in perfused rat liver following ethanol treatment",

abstract = "The oxygen gradient across the liver lobule was measured in isolated, hemoglobin-free perfused livers from control and ethanol-treated rats using micro-light guides and miniature oxygen electrodes. Both techniques yielded similar values for the lobular, periportal and pericentral oxygen gradients. Oxygen uptake increased 33% in livers from rats treated with ethanol for 4 to 6 weeks. In addition, the pericentral oxygen gradient increased by 100%, but the periportal gradient was unchanged. These observations suggest that chronic ethanol treatment may increase the rate of cellular respiration in ethanol-induced inhibition of glycolysis which predominates in pericentral hepatocytes.",

keywords = "Ethanol, Liver, Oxygen gradient, Rat",

author = "Sungchul Ji and Lemasters, {John J.} and Vickie Christenson and Thurman, {Ronald G.}",

note = "Funding Information: 1Supported in part by Grants AA-04853, AA-03624 and GM-28999. R.G.T. is the recipient of Research Career Development Award AA-00033 and J.J.L. is an Established Investigator of the American Heart Association. 2Present address: Department of Pharmacology, College of Pharmacy, Rutgers University, New Brunswick, NJ 08854. 3Requests for reprints should be addressed to Dr. R. G. Thurman, Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27514.",

year = "1983",

doi = "10.1016/0091-3057(83)90214-9",

language = "English (US)",

volume = "18",

pages = "439--442",

journal = "Pharmacology Biochemistry and Behavior",

issn = "0091-3057",

publisher = "Elsevier Inc.",

number = "SUPPL. 1",

}

TY - JOUR

T1 - Selective increase in pericentral oxygen gradient in perfused rat liver following ethanol treatment

AU - Ji, Sungchul

AU - Lemasters, John J.

AU - Christenson, Vickie

AU - Thurman, Ronald G.

N1 - Funding Information: 1Supported in part by Grants AA-04853, AA-03624 and GM-28999. R.G.T. is the recipient of Research Career Development Award AA-00033 and J.J.L. is an Established Investigator of the American Heart Association. 2Present address: Department of Pharmacology, College of Pharmacy, Rutgers University, New Brunswick, NJ 08854. 3Requests for reprints should be addressed to Dr. R. G. Thurman, Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27514.

PY - 1983

Y1 - 1983

N2 - The oxygen gradient across the liver lobule was measured in isolated, hemoglobin-free perfused livers from control and ethanol-treated rats using micro-light guides and miniature oxygen electrodes. Both techniques yielded similar values for the lobular, periportal and pericentral oxygen gradients. Oxygen uptake increased 33% in livers from rats treated with ethanol for 4 to 6 weeks. In addition, the pericentral oxygen gradient increased by 100%, but the periportal gradient was unchanged. These observations suggest that chronic ethanol treatment may increase the rate of cellular respiration in ethanol-induced inhibition of glycolysis which predominates in pericentral hepatocytes.

AB - The oxygen gradient across the liver lobule was measured in isolated, hemoglobin-free perfused livers from control and ethanol-treated rats using micro-light guides and miniature oxygen electrodes. Both techniques yielded similar values for the lobular, periportal and pericentral oxygen gradients. Oxygen uptake increased 33% in livers from rats treated with ethanol for 4 to 6 weeks. In addition, the pericentral oxygen gradient increased by 100%, but the periportal gradient was unchanged. These observations suggest that chronic ethanol treatment may increase the rate of cellular respiration in ethanol-induced inhibition of glycolysis which predominates in pericentral hepatocytes.

KW - Ethanol

KW - Liver

KW - Oxygen gradient

KW - Rat

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U2 - 10.1016/0091-3057(83)90214-9

DO - 10.1016/0091-3057(83)90214-9

M3 - Article

C2 - 6685302

AN - SCOPUS:0021276055

SN - 0091-3057

VL - 18

SP - 439

EP - 442

JO - Pharmacology Biochemistry and Behavior

JF - Pharmacology Biochemistry and Behavior

IS - SUPPL. 1

ER -

Selective increase in pericentral oxygen gradient in perfused rat liver following ethanol treatment

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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