TY - GEN
T1 - Selective regulation of protein bioactivity and cell adhesion & migration via PEG microdomains on biopolymers
AU - Tziampazis, Evangelos
AU - Cassaday, Jason A.
AU - Kohn, Joachim
AU - Moghe, Prabhas V.
PY - 1999
Y1 - 1999
N2 - Interactions between polyethylene glycol (PEG)-containing biomaterials, adsorbed extracellular matrix proteins and resultant cell functions were studied, focusing on cellular responses at intermediate PEG levels, in regimes where protein adsorption is allowed to occur. A series of polymers were synthesized through random block copolymerization of a derivative of tyrosine with increasing PEG amounts. PEG effects on the protein conformation affect, among others, protein mobility and the ability of cells to reorganize fibronectin. The potential of using PEG microdomains to regulate independently the activity and mobility of ECM proteins, and modulate and optimize cell adhesion and migration is discussed.
AB - Interactions between polyethylene glycol (PEG)-containing biomaterials, adsorbed extracellular matrix proteins and resultant cell functions were studied, focusing on cellular responses at intermediate PEG levels, in regimes where protein adsorption is allowed to occur. A series of polymers were synthesized through random block copolymerization of a derivative of tyrosine with increasing PEG amounts. PEG effects on the protein conformation affect, among others, protein mobility and the ability of cells to reorganize fibronectin. The potential of using PEG microdomains to regulate independently the activity and mobility of ECM proteins, and modulate and optimize cell adhesion and migration is discussed.
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M3 - Conference contribution
AN - SCOPUS:0033335146
SN - 0780356756
T3 - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
SP - 743
BT - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PB - IEEE
T2 - Proceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
Y2 - 13 October 1999 through 16 October 1999
ER -