Abstract
The first general method for the chemoselective synthesis of α,α-dideuterio alcohols directly from feedstock carboxylic acids under single electron transfer conditions using SmI2 is reported. This reaction proceeds after the activation of Sm(II) with a Lewis base, results in excellent levels of deuterium incorporation across a wide range of substrates, and represents an attractive alternative to processes mediated by pyrophoric alkali metal deuterides.
Original language | English (US) |
---|---|
Pages (from-to) | 5052-5055 |
Number of pages | 4 |
Journal | Organic letters |
Volume | 16 |
Issue number | 19 |
DOIs | |
State | Published - Oct 3 2014 |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry