The single-step synthesis of 3-hydroxy carboxylic acids from readily available Meldrum’s acids involves a selective mono reduction using a smI2-H2O complex to give products in high crude purity, and it represents a considerable advancement over other methods for the synthesis of 3-hydroxy acids. the protocol includes a detailed guide to the preparation of a single electron-reducing smI2-H2O complex and describes two representative examples of the methodology: mono reduction of a fully saturated Meldrum’s acid (5-(4-bromobenzyl)-2, 2-dimethyl-1, 3-dioxane-4, 6-dione) and tandem conjugate reduction-selective mono reduction of a, b-unsaturated Meldrum’s acid (5-(4-methoxybenzylidene)-2, 2-dimethyl-1, 3-dioxane-4, 6-dione). The protocol for selective mono reduction of Meldrum’s acids takes ˜6 h to complete.
All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)