Self-assembled nucleic acid nanostructures for cancer theranostic medicines

Jinglin Fu, Gabriele Stankeviciute, Sung Won Oh, John Collins, Yinghui Zhong, Ting Zhang

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Theranostic medicine has become more promising in cancer treatment, where the cancer diagnosis and chemotherapy are combined for early diagnosis and precise treatment with improved efficacy and reduced side effects. Nanotechnology has played a critical role in developing various nanomaterials with engendered smart functions and targeted delivery. The rapid development of structural DNA nanotechnology has enabled the design and fabrication of complex nanostructures with prescribed 1D, 2D and 3D patterns in vitro and in vivo. Self-assembled DNA nanostructures can serve as drug delivery platforms that are integrated with various functions ranging from molecular recognition and computations, dynamically structural switch to carrying molecular payloads and selectively release. In this review, we summarize recent exciting progress of using DNA nanostructures to engineer novel smart drug-delivery systems potential for treating cancer.

Original languageEnglish (US)
Pages (from-to)1815-1828
Number of pages14
JournalCurrent topics in medicinal chemistry
Volume17
Issue number16
DOIs
StatePublished - 2017

All Science Journal Classification (ASJC) codes

  • Drug Discovery

Keywords

  • Cancer theranostics
  • DNA nanorobot
  • DNA nanotechnology
  • Smart drug delivery
  • Spherical nucleic acids

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