Self-assembled nucleic acid nanostructures for cancer theranostic medicines

Jinglin Fu; Gabriele Stankeviciute; Sung Won Oh; John Collins; Yinghui Zhong; Ting Zhang

doi:10.2174/1568026617666161122115722

Self-assembled nucleic acid nanostructures for cancer theranostic medicines

Jinglin Fu, Gabriele Stankeviciute, Sung Won Oh, John Collins, Yinghui Zhong, Ting Zhang

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

Theranostic medicine has become more promising in cancer treatment, where the cancer diagnosis and chemotherapy are combined for early diagnosis and precise treatment with improved efficacy and reduced side effects. Nanotechnology has played a critical role in developing various nanomaterials with engendered smart functions and targeted delivery. The rapid development of structural DNA nanotechnology has enabled the design and fabrication of complex nanostructures with prescribed 1D, 2D and 3D patterns in vitro and in vivo. Self-assembled DNA nanostructures can serve as drug delivery platforms that are integrated with various functions ranging from molecular recognition and computations, dynamically structural switch to carrying molecular payloads and selectively release. In this review, we summarize recent exciting progress of using DNA nanostructures to engineer novel smart drug-delivery systems potential for treating cancer.

Original language	English (US)
Pages (from-to)	1815-1828
Number of pages	14
Journal	Current topics in medicinal chemistry
Volume	17
Issue number	16
DOIs	https://doi.org/10.2174/1568026617666161122115722
State	Published - 2017

All Science Journal Classification (ASJC) codes

Drug Discovery

Keywords

Cancer theranostics
DNA nanorobot
DNA nanotechnology
Smart drug delivery
Spherical nucleic acids

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10.2174/1568026617666161122115722

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abstract = "Theranostic medicine has become more promising in cancer treatment, where the cancer diagnosis and chemotherapy are combined for early diagnosis and precise treatment with improved efficacy and reduced side effects. Nanotechnology has played a critical role in developing various nanomaterials with engendered smart functions and targeted delivery. The rapid development of structural DNA nanotechnology has enabled the design and fabrication of complex nanostructures with prescribed 1D, 2D and 3D patterns in vitro and in vivo. Self-assembled DNA nanostructures can serve as drug delivery platforms that are integrated with various functions ranging from molecular recognition and computations, dynamically structural switch to carrying molecular payloads and selectively release. In this review, we summarize recent exciting progress of using DNA nanostructures to engineer novel smart drug-delivery systems potential for treating cancer.",

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AU - Fu, Jinglin

AU - Stankeviciute, Gabriele

AU - Oh, Sung Won

AU - Collins, John

AU - Zhong, Yinghui

AU - Zhang, Ting

PY - 2017

Y1 - 2017

N2 - Theranostic medicine has become more promising in cancer treatment, where the cancer diagnosis and chemotherapy are combined for early diagnosis and precise treatment with improved efficacy and reduced side effects. Nanotechnology has played a critical role in developing various nanomaterials with engendered smart functions and targeted delivery. The rapid development of structural DNA nanotechnology has enabled the design and fabrication of complex nanostructures with prescribed 1D, 2D and 3D patterns in vitro and in vivo. Self-assembled DNA nanostructures can serve as drug delivery platforms that are integrated with various functions ranging from molecular recognition and computations, dynamically structural switch to carrying molecular payloads and selectively release. In this review, we summarize recent exciting progress of using DNA nanostructures to engineer novel smart drug-delivery systems potential for treating cancer.

AB - Theranostic medicine has become more promising in cancer treatment, where the cancer diagnosis and chemotherapy are combined for early diagnosis and precise treatment with improved efficacy and reduced side effects. Nanotechnology has played a critical role in developing various nanomaterials with engendered smart functions and targeted delivery. The rapid development of structural DNA nanotechnology has enabled the design and fabrication of complex nanostructures with prescribed 1D, 2D and 3D patterns in vitro and in vivo. Self-assembled DNA nanostructures can serve as drug delivery platforms that are integrated with various functions ranging from molecular recognition and computations, dynamically structural switch to carrying molecular payloads and selectively release. In this review, we summarize recent exciting progress of using DNA nanostructures to engineer novel smart drug-delivery systems potential for treating cancer.

KW - Cancer theranostics

KW - DNA nanorobot

KW - DNA nanotechnology

KW - Smart drug delivery

KW - Spherical nucleic acids

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Self-assembled nucleic acid nanostructures for cancer theranostic medicines

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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