Self-reported non-adherence to immune-suppressant therapy in liver transplant recipients: Demographic, interpersonal, and intrapersonal factors

Sangeeta Lamba, Roxanne Nagurka, Kunj K. Desai, Shaun J. Chun, Bart Holland, Baburao Koneru

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Adherence to immune suppressants and follow-up care regimen is important in achieving optimal long-term outcomes after organ transplantation. To identify patients most at risk for non-adherence, this cross-sectional, descriptive study explores the prevalence and correlates of non-adherence to immune-suppressant therapy among liver recipients. Anonymous questionnaires mailed consisted of the domains: (i) adherence barriers to immune suppressants, (ii) immune suppressants knowledge, (iii) demographics, (iv) social support, (v) medical co-morbidities, and (vi) healthcare locus of control and other beliefs. Overall response was 49% (281/572). Data analyzed for those transplanted within 10yr of study reveal 50% (119/237) recipients or 9.2/100 person years reporting non-adherence. Non-adherence was reported highest in the 2-5yr post-transplant phase (69/123, 56%). The highest immune-suppressant non-adherence rates were in recipients who are: divorced (26/34, 76%, p=0.0093), have a history of substance or alcohol use (42/69, 61%, p=0.0354), have mental health needs (50/84, 60%, p=0.0336), those who missed clinic appointments (25/30, 83%, p<0.0001), and did not maintain medication logs (71/122, 58%, p=0.0168). Respondents who were non-adherent with physician appointments were more than four and a half times as likely (OR 4.7, 95% CI 1.5-14.7, p=0.008) to be non-adherent with immune suppressants. In conclusion, half of our respondents report non-adherence to immune suppressants. Factors identified may assist clinicians to gauge patients' non-adherence risk and target resources.

Original languageEnglish (US)
Pages (from-to)328-335
Number of pages8
JournalClinical Transplantation
Volume26
Issue number2
DOIs
StatePublished - Mar 1 2012

All Science Journal Classification (ASJC) codes

  • Transplantation

Keywords

  • Adherence
  • Compliance
  • Immune suppression
  • Immune-suppressant
  • Liver transplantation

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