Sensitivity of ultrasound in detecting spina bifida

Nicholas J. Wald; Howard S. Cuckle; James E. Haddow; Richard A. Doherty; George J. Knight; Glenn E. Palomaki; Douglas W. Hershey; Beth A. Pletcher; Carrie D. Agnelli; Harris L. Cohen; Loretta P. Lawrence; Gittel Silverberg; Keith F. Rawlinson; J. G. Thornton; R. J. Lilford; Allan S. Nadel; Lewis B. Holmes; Fredric D. Frigoletto; Beryl R. Benacerraf

doi:10.1056/NEJM199103143241112

Sensitivity of ultrasound in detecting spina bifida

Nicholas J. Wald, Howard S. Cuckle, James E. Haddow, Richard A. Doherty, George J. Knight, Glenn E. Palomaki, Douglas W. Hershey, Beth A. Pletcher, Carrie D. Agnelli, Harris L. Cohen, Loretta P. Lawrence, Gittel Silverberg, Keith F. Rawlinson, J. G. Thornton, R. J. Lilford, Allan S. Nadel, Lewis B. Holmes, Fredric D. Frigoletto, Beryl R. Benacerraf

Research output: Contribution to journal › Letter › peer-review

12 Scopus citations

Abstract

To the Editor: We believe that Nadel and his colleagues (Aug. 30 issue)¹ are incorrect in suggesting that there is no need for amniocentesis in patients with elevated maternal serum alpha-fetoprotein levels and a normal ultrasonographic examination. Their conclusion rests on the belief that ultrasonography will virtually never miss a case of open spina bifida (detection rate virtually 100 percent) in the fetuses of women with raised maternal serum alpha-fetoprotein levels and on the assumption that there will be no false positive results. Their own estimate of the detection rate is based on their identification of 31 of 31 cases.

Original language	English (US)
Pages (from-to)	769-772
Number of pages	4
Journal	New England Journal of Medicine
Volume	324
Issue number	11
DOIs	https://doi.org/10.1056/NEJM199103143241112
State	Published - Mar 14 1991
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Medicine

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Wald, N. J., Cuckle, H. S., Haddow, J. E., Doherty, R. A., Knight, G. J., Palomaki, G. E., Hershey, D. W., Pletcher, B. A., Agnelli, C. D., Cohen, H. L., Lawrence, L. P., Silverberg, G., Rawlinson, K. F., Thornton, J. G., Lilford, R. J., Nadel, A. S., Holmes, L. B., Frigoletto, F. D., & Benacerraf, B. R. (1991). Sensitivity of ultrasound in detecting spina bifida. New England Journal of Medicine, 324(11), 769-772. https://doi.org/10.1056/NEJM199103143241112

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title = "Sensitivity of ultrasound in detecting spina bifida",

abstract = "To the Editor: We believe that Nadel and his colleagues (Aug. 30 issue)1 are incorrect in suggesting that there is no need for amniocentesis in patients with elevated maternal serum alpha-fetoprotein levels and a normal ultrasonographic examination. Their conclusion rests on the belief that ultrasonography will virtually never miss a case of open spina bifida (detection rate virtually 100 percent) in the fetuses of women with raised maternal serum alpha-fetoprotein levels and on the assumption that there will be no false positive results. Their own estimate of the detection rate is based on their identification of 31 of 31 cases.",

author = "Wald, {Nicholas J.} and Cuckle, {Howard S.} and Haddow, {James E.} and Doherty, {Richard A.} and Knight, {George J.} and Palomaki, {Glenn E.} and Hershey, {Douglas W.} and Pletcher, {Beth A.} and Agnelli, {Carrie D.} and Cohen, {Harris L.} and Lawrence, {Loretta P.} and Gittel Silverberg and Rawlinson, {Keith F.} and Thornton, {J. G.} and Lilford, {R. J.} and Nadel, {Allan S.} and Holmes, {Lewis B.} and Frigoletto, {Fredric D.} and Benacerraf, {Beryl R.}",

year = "1991",

month = mar,

day = "14",

doi = "10.1056/NEJM199103143241112",

language = "English (US)",

volume = "324",

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journal = "New England Journal of Medicine",

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Wald, NJ, Cuckle, HS, Haddow, JE, Doherty, RA, Knight, GJ, Palomaki, GE, Hershey, DW, Pletcher, BA, Agnelli, CD, Cohen, HL, Lawrence, LP, Silverberg, G, Rawlinson, KF, Thornton, JG, Lilford, RJ, Nadel, AS, Holmes, LB, Frigoletto, FD & Benacerraf, BR 1991, 'Sensitivity of ultrasound in detecting spina bifida', New England Journal of Medicine, vol. 324, no. 11, pp. 769-772. https://doi.org/10.1056/NEJM199103143241112

TY - JOUR

T1 - Sensitivity of ultrasound in detecting spina bifida

AU - Wald, Nicholas J.

AU - Cuckle, Howard S.

AU - Haddow, James E.

AU - Doherty, Richard A.

AU - Knight, George J.

AU - Palomaki, Glenn E.

AU - Hershey, Douglas W.

AU - Pletcher, Beth A.

AU - Agnelli, Carrie D.

AU - Cohen, Harris L.

AU - Lawrence, Loretta P.

AU - Silverberg, Gittel

AU - Rawlinson, Keith F.

AU - Thornton, J. G.

AU - Lilford, R. J.

AU - Nadel, Allan S.

AU - Holmes, Lewis B.

AU - Frigoletto, Fredric D.

AU - Benacerraf, Beryl R.

PY - 1991/3/14

Y1 - 1991/3/14

N2 - To the Editor: We believe that Nadel and his colleagues (Aug. 30 issue)1 are incorrect in suggesting that there is no need for amniocentesis in patients with elevated maternal serum alpha-fetoprotein levels and a normal ultrasonographic examination. Their conclusion rests on the belief that ultrasonography will virtually never miss a case of open spina bifida (detection rate virtually 100 percent) in the fetuses of women with raised maternal serum alpha-fetoprotein levels and on the assumption that there will be no false positive results. Their own estimate of the detection rate is based on their identification of 31 of 31 cases.

AB - To the Editor: We believe that Nadel and his colleagues (Aug. 30 issue)1 are incorrect in suggesting that there is no need for amniocentesis in patients with elevated maternal serum alpha-fetoprotein levels and a normal ultrasonographic examination. Their conclusion rests on the belief that ultrasonography will virtually never miss a case of open spina bifida (detection rate virtually 100 percent) in the fetuses of women with raised maternal serum alpha-fetoprotein levels and on the assumption that there will be no false positive results. Their own estimate of the detection rate is based on their identification of 31 of 31 cases.

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EP - 772

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 11

ER -

Sensitivity of ultrasound in detecting spina bifida

Abstract

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