Sequence and organization of the human mitochondrial genome

S. Anderson; A. T. Bankier; B. G. Barrell; M. H.L. De Bruijn; A. R. Coulson; J. Drouin; I. C. Eperon; D. P. Nierlich; B. A. Roe; F. Sanger; P. H. Schreier; A. J.H. Smith; R. Staden; I. G. Young

doi:10.1038/290457a0

Sequence and organization of the human mitochondrial genome

S. Anderson, A. T. Bankier, B. G. Barrell, M. H.L. De Bruijn, A. R. Coulson, J. Drouin, I. C. Eperon, D. P. Nierlich, B. A. Roe, F. Sanger, P. H. Schreier, A. J.H. Smith, R. Staden, I. G. Young

School of Arts and Sciences, Molecular Biology & Biochemistry

Research output: Contribution to journal › Article › peer-review

7945 Scopus citations

Abstract

The complete sequence of the 16,569-base pair human mitochondrial genome is presented. The genes for the 12S and 16S rRNAs, 22 tRNAs, cytochrome c oxidase subunits I, II and III, ATPase subunit 6, cytochrome b and eight other predicted protein coding genes have been located. The sequence shows extreme economy in that the genes have none or only a few noncoding bases between them, and in many cases the termination codons are not coded in the DNA but are created post-transcriptionally by polyadenylation of the mRNAs.

Original language	English (US)
Pages (from-to)	457-465
Number of pages	9
Journal	Nature
Volume	290
Issue number	5806
DOIs	https://doi.org/10.1038/290457a0
State	Published - 1981

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title = "Sequence and organization of the human mitochondrial genome",

abstract = "The complete sequence of the 16,569-base pair human mitochondrial genome is presented. The genes for the 12S and 16S rRNAs, 22 tRNAs, cytochrome c oxidase subunits I, II and III, ATPase subunit 6, cytochrome b and eight other predicted protein coding genes have been located. The sequence shows extreme economy in that the genes have none or only a few noncoding bases between them, and in many cases the termination codons are not coded in the DNA but are created post-transcriptionally by polyadenylation of the mRNAs.",

author = "S. Anderson and Bankier, {A. T.} and Barrell, {B. G.} and {De Bruijn}, {M. H.L.} and Coulson, {A. R.} and J. Drouin and Eperon, {I. C.} and Nierlich, {D. P.} and Roe, {B. A.} and F. Sanger and Schreier, {P. H.} and Smith, {A. J.H.} and R. Staden and Young, {I. G.}",

year = "1981",

doi = "10.1038/290457a0",

language = "English (US)",

volume = "290",

pages = "457--465",

journal = "Nature",

issn = "0028-0836",

publisher = "Nature Publishing Group",

number = "5806",

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TY - JOUR

T1 - Sequence and organization of the human mitochondrial genome

AU - Anderson, S.

AU - Bankier, A. T.

AU - Barrell, B. G.

AU - De Bruijn, M. H.L.

AU - Coulson, A. R.

AU - Drouin, J.

AU - Eperon, I. C.

AU - Nierlich, D. P.

AU - Roe, B. A.

AU - Sanger, F.

AU - Schreier, P. H.

AU - Smith, A. J.H.

AU - Staden, R.

AU - Young, I. G.

PY - 1981

Y1 - 1981

N2 - The complete sequence of the 16,569-base pair human mitochondrial genome is presented. The genes for the 12S and 16S rRNAs, 22 tRNAs, cytochrome c oxidase subunits I, II and III, ATPase subunit 6, cytochrome b and eight other predicted protein coding genes have been located. The sequence shows extreme economy in that the genes have none or only a few noncoding bases between them, and in many cases the termination codons are not coded in the DNA but are created post-transcriptionally by polyadenylation of the mRNAs.

AB - The complete sequence of the 16,569-base pair human mitochondrial genome is presented. The genes for the 12S and 16S rRNAs, 22 tRNAs, cytochrome c oxidase subunits I, II and III, ATPase subunit 6, cytochrome b and eight other predicted protein coding genes have been located. The sequence shows extreme economy in that the genes have none or only a few noncoding bases between them, and in many cases the termination codons are not coded in the DNA but are created post-transcriptionally by polyadenylation of the mRNAs.

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DO - 10.1038/290457a0

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VL - 290

SP - 457

EP - 465

JO - Nature

JF - Nature

IS - 5806

ER -

Sequence and organization of the human mitochondrial genome

Abstract

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