Sequence recognition of DNA by Lexitropsins

D. S. Goodsell

doi:10.2174/0929867003373319

Sequence recognition of DNA by Lexitropsins

D. S. Goodsell

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Lexitropsins are modular polyamide molecules that are designed to "read" the base sequence of DNA. Lexitropsins constructed of three types of subunits-pyrrole, imidazole and hydroxypyrrole-allow full recognition of DNA base sequences. Structural studies have revealed the atomic basis of this specificity. Theoretical studies have explored the effectiveness of lexitropsins in targeting a given sequence within a genome, and have been used to analyze and improve lexitropsin design.

Original language	English (US)
Pages (from-to)	509-516
Number of pages	8
Journal	Current Medicinal Chemistry
Volume	8
Issue number	5
DOIs	https://doi.org/10.2174/0929867003373319
State	Published - 2001
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Pharmacology
Drug Discovery
Organic Chemistry

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10.2174/0929867003373319

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AB - Lexitropsins are modular polyamide molecules that are designed to "read" the base sequence of DNA. Lexitropsins constructed of three types of subunits-pyrrole, imidazole and hydroxypyrrole-allow full recognition of DNA base sequences. Structural studies have revealed the atomic basis of this specificity. Theoretical studies have explored the effectiveness of lexitropsins in targeting a given sequence within a genome, and have been used to analyze and improve lexitropsin design.

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Sequence recognition of DNA by Lexitropsins

Abstract

All Science Journal Classification (ASJC) codes

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