Serial pathogenesis study of SIV brain infection.

L. R. Sharer, J. Michaels, M. Murphey-Corb, F. S. Hu, D. J. Kuebler, L. N. Martin, G. B. Baskin

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52 Scopus citations


A serial study of early SIV brain infection revealed initial involvement of leptomeninges, followed by perivascular infection of brain parenchyma. Severity of SIV encephalitis correlated with severity of systemic disease rather than with length of infection. Diffuse white matter disease was not observed, and there was little evidence of SIV infection of brain endothelial cells. SIV infection of leptomeninges is separate from infection of the brain, which appears to be due to transvascular spread of infected monocytes/macrophages.

Original languageEnglish (US)
Pages (from-to)211-217
Number of pages7
JournalJournal of medical primatology
Issue number4
StatePublished - Jun 1991

All Science Journal Classification (ASJC) codes

  • Animal Science and Zoology
  • veterinary(all)

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