Serotonergic control of prolactin release in male rats

J. P. Advis; J. W. Simpkins; J. Bennett; J. Meites

doi:10.1016/0024-3205(79)90332-1

Serotonergic control of prolactin release in male rats

J. P. Advis, J. W. Simpkins, J. Bennett, J. Meites

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

To further clarify the relationship between the central serotonergic system and the control of prolactin secretion, we studied the effect of dorsal raphe' lesions, electrical stimulation of the midbrain raphe' nucleus and treatment with parachlorophenylalanine (PCPA) on prolactin secretion. Radio frequency destruction of serotonergic cell bodies in the midbrain dorsal raphe' nucleus or PCPA decreased forebrain serotonin (5HT) and 5-hydroxyindoleacetic acid (5HIAA) concentration and prolactin secretion. Electrical stimulation of the raphe' increased forebrain serotonin turnover and prolactin secretion. These observations indicate that serotonergic neurons located in the raphe' nuclei may be involved in regulating prolactin secretion in male rats.

Original language	English (US)
Pages (from-to)	359-365
Number of pages	7
Journal	Life Sciences
Volume	24
Issue number	4
DOIs	https://doi.org/10.1016/0024-3205(79)90332-1
State	Published - Jan 22 1979
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/0024-3205(79)90332-1

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title = "Serotonergic control of prolactin release in male rats",

abstract = "To further clarify the relationship between the central serotonergic system and the control of prolactin secretion, we studied the effect of dorsal raphe' lesions, electrical stimulation of the midbrain raphe' nucleus and treatment with parachlorophenylalanine (PCPA) on prolactin secretion. Radio frequency destruction of serotonergic cell bodies in the midbrain dorsal raphe' nucleus or PCPA decreased forebrain serotonin (5HT) and 5-hydroxyindoleacetic acid (5HIAA) concentration and prolactin secretion. Electrical stimulation of the raphe' increased forebrain serotonin turnover and prolactin secretion. These observations indicate that serotonergic neurons located in the raphe' nuclei may be involved in regulating prolactin secretion in male rats.",

author = "Advis, {J. P.} and Simpkins, {J. W.} and J. Bennett and J. Meites",

note = "Funding Information: Dahlstr{\"o}m and Fuxe (6) showed that almost all of the 5HT containing cell bodies were restricted to a narrow group of neurons, the raphe' nuclei, lying in the mid portions of the lower pons and upper brain stem . These 5HT contain ing neurons, particularly the dorsal and median nuclei, are believed to be 1Present address : Department of Physiology, University of Texas, Dallas, TX 75219 . ZPresent address : Department of Physiology and Pharmacy, University of Florida, JHMHC, Box J-4, 6ainesville, FL 32610 . 3Department of Pharmacology, Michigan State University, East Lansing, Michigan 48824. 4Aided in part by NIH research grant AM 04784 from the National Institute of Arthritis, Metabolism and Digestive Diseases . 5Published with the approval of the Michigan Agriculture Experiment Station as Journal Article No .",

year = "1979",

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doi = "10.1016/0024-3205(79)90332-1",

language = "English (US)",

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pages = "359--365",

journal = "Life Sciences",

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T1 - Serotonergic control of prolactin release in male rats

AU - Advis, J. P.

AU - Simpkins, J. W.

AU - Bennett, J.

AU - Meites, J.

N1 - Funding Information: Dahlström and Fuxe (6) showed that almost all of the 5HT containing cell bodies were restricted to a narrow group of neurons, the raphe' nuclei, lying in the mid portions of the lower pons and upper brain stem . These 5HT contain ing neurons, particularly the dorsal and median nuclei, are believed to be 1Present address : Department of Physiology, University of Texas, Dallas, TX 75219 . ZPresent address : Department of Physiology and Pharmacy, University of Florida, JHMHC, Box J-4, 6ainesville, FL 32610 . 3Department of Pharmacology, Michigan State University, East Lansing, Michigan 48824. 4Aided in part by NIH research grant AM 04784 from the National Institute of Arthritis, Metabolism and Digestive Diseases . 5Published with the approval of the Michigan Agriculture Experiment Station as Journal Article No .

PY - 1979/1/22

Y1 - 1979/1/22

N2 - To further clarify the relationship between the central serotonergic system and the control of prolactin secretion, we studied the effect of dorsal raphe' lesions, electrical stimulation of the midbrain raphe' nucleus and treatment with parachlorophenylalanine (PCPA) on prolactin secretion. Radio frequency destruction of serotonergic cell bodies in the midbrain dorsal raphe' nucleus or PCPA decreased forebrain serotonin (5HT) and 5-hydroxyindoleacetic acid (5HIAA) concentration and prolactin secretion. Electrical stimulation of the raphe' increased forebrain serotonin turnover and prolactin secretion. These observations indicate that serotonergic neurons located in the raphe' nuclei may be involved in regulating prolactin secretion in male rats.

AB - To further clarify the relationship between the central serotonergic system and the control of prolactin secretion, we studied the effect of dorsal raphe' lesions, electrical stimulation of the midbrain raphe' nucleus and treatment with parachlorophenylalanine (PCPA) on prolactin secretion. Radio frequency destruction of serotonergic cell bodies in the midbrain dorsal raphe' nucleus or PCPA decreased forebrain serotonin (5HT) and 5-hydroxyindoleacetic acid (5HIAA) concentration and prolactin secretion. Electrical stimulation of the raphe' increased forebrain serotonin turnover and prolactin secretion. These observations indicate that serotonergic neurons located in the raphe' nuclei may be involved in regulating prolactin secretion in male rats.

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JF - Life Sciences

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Serotonergic control of prolactin release in male rats

Abstract

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