Serum differentially alters the antifungal properties of echinocandin drugs

Padmaja Paderu, Guillermo Garcia-Effron, Sergey Balashov, Guillaume Delmas, Steven Park, David S. Perlin

Research output: Contribution to journalArticlepeer-review

95 Scopus citations

Abstract

Antifungal efficacies of the echinocandin drugs caspofungin, micafungin, and anidulafungin were reduced significantly in the presence of 50% human serum, which yielded nearly equivalent MICs or minimum effective concentrations against diverse Candida spp. and Aspergillus spp. Consistent with a direct drug interaction, serum decreased the sensitivity of glucan synthase to echinocandin drugs.

Original languageEnglish (US)
Pages (from-to)2253-2256
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume51
Issue number6
DOIs
StatePublished - Jun 2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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