Serum levels of unbound free fatty acids. I: Normative data in term newborn infants

Mahesh N. Patel, Alan M. Kleinfeld, Gary V. Richeiri, Sandhya Ruben, Mark Hiatt, Thomas Hegyi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Free fatty acids (FFA) play essential roles in maintaining physiologic homeostasis in the newborn infant. Most of the FFA in serum is carried in complex with albumin, but a small fraction remains unbound in the aqueous phase. This study's goal is to report the values of serum levels of unbound free fatty acids (FFAu) in pregnant women and their newborn infants at term gestation. The measurements were made possible by the availability of the fluorescent probe for unbound FFA, acrylodated intestinal fatty acid binding protein (ADIFAB). Twenty-two mother-infant pairs were enrolled in the study. Maternal levels were obtained immediately before delivery, cord levels at the time of delivery, and infant levels after 24 hours of age. The level of FFAu measured in maternal samples was 11.8 +/− 4 nM, in cord samples 9.2 +/− 4 nM, and in infants 13.9 +/− 3 nM. These population averages are considerably greater than those observed in healthy adults (7.5 +/− 2.5 nM). No correlation was found between cord levels and birthweight, gestational age, labor duration, mode of deliver, and infant or maternal temperature. This investigation is the first to measure FFAu in a group of mothers and their infants and provides the technique for future investigations of the biologic activity of free fatty acids.

Original languageEnglish (US)
Pages (from-to)81-84
Number of pages4
JournalJournal of the American College of Nutrition
Volume16
Issue number1
DOIs
StatePublished - Feb 1 1997

Fingerprint

Nonesterified Fatty Acids
Mothers
Newborn Infant
Serum
Fatty Acid-Binding Proteins
Fluorescent Dyes
Gestational Age
Pregnant Women
Albumins
Homeostasis
Pregnancy
Temperature
Population

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Keywords

  • Newborn infant
  • Unbound fatty acid

Cite this

Patel, Mahesh N. ; Kleinfeld, Alan M. ; Richeiri, Gary V. ; Ruben, Sandhya ; Hiatt, Mark ; Hegyi, Thomas. / Serum levels of unbound free fatty acids. I : Normative data in term newborn infants. In: Journal of the American College of Nutrition. 1997 ; Vol. 16, No. 1. pp. 81-84.
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Serum levels of unbound free fatty acids. I : Normative data in term newborn infants. / Patel, Mahesh N.; Kleinfeld, Alan M.; Richeiri, Gary V.; Ruben, Sandhya; Hiatt, Mark; Hegyi, Thomas.

In: Journal of the American College of Nutrition, Vol. 16, No. 1, 01.02.1997, p. 81-84.

Research output: Contribution to journalArticle

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