Serum monocyte chemokine protein-1 levels before and after parathyroidectomy in patients with primary hyperparathyroidism

Hemal Patel, Stanley Trooskin, Sue Shapses, Wei Sun, Xiangbing Wang

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Methods: Forty-three PHPT patients, age 56 ± 12 years, underwent minimally invasive parathyroidectomy. Serum samples were collected at 0 and 15 to 20 minutes after parathyroid adenoma removal. Serum samples were stored at -70°C until time of assay.

Objective: To investigate the effects of parathyroidectomy on serum monocyte chemokine protein-1 (MCP-1) levels in patients with primary hyperparathyroidism (PHPT).

Results: In 40 PHPT patients with a single adenoma, MCP-1 levels decreased from 342 ± 103 to 250 ± 77 pg/mL (P<.001) 15 to 20 minutes after parathyroid adenoma removal. MCP-1 levels were positively correlated with intact parathyroid hormone (PTH) levels (R = 0.47; P<.01). In 3 PHPT patients with double parathyroid adenoma, MCP-1 levels did not decrease after removal of the first adenoma but decreased 15 to 20 minutes after second adenoma removal.

Conclusion: Our results provide evidence that the decrease in serum intact PTH due to minimally invasive parathyroidectomy results in an immediate decrease in serum MCP-1 levels.

Original languageEnglish (US)
Pages (from-to)1165-1169
Number of pages5
JournalEndocrine Practice
Volume20
Issue number11
DOIs
StatePublished - Nov 1 2014

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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