Severe folate restriction results in depletion of and alteration in the composition of the intracellular folate pool, moderate sensitization to methotrexate and trimetrexate, upregulation of endogenous DHFR activity, and overexpression of metallothionein II and folate receptor alpha that, upon folate repletion, confer drug resistance to CHL cells
Wei Yong Zhu
, M. Bunni
, D. G. Priest
, J. L. DiCapua
, J. M. Dressler
, Z. Chen
, Peter W. Melera
Research output: Contribution to journal › Article › peer-review
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