Severe gastrointestinal involvement in children with the acquired immunodeficiency syndrome

Lucille C. McLoughlin, Kenneth S. Nord, Vijay V. Joshi, James Oleske

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Five children with the acquired immunodeficiency syndrome (AIDS) and unusual gastrointestinal disease are described. Two children presented with malnutrition, abdominal distention, and diarrhea. One was found to have moderately severe villus atrophy on jejunal biopsy and was initially thought to have celiac disease. Jejunal biopsy from the second child revealed infiltration of the mucosa with acid-fast bacilli-laden macrophages. A third child suffered recurrent abdominal pain, progressive weight loss, diarrhea, and severe gastrointestinal hemorrhage secondary to infection with cytomegalovirus. Pseudomembranous necrotizing jejunitis associated with overgrowth of Klebsiella pneumoniae in the duodenal fluid occurred in one patient. The fifth child presented in the newborn period with Serratiu marces-cens cholecystitis. Gastrointestinal disease in children with AIDS may be due to idiopathic villus atrophy and bacterial or opportunistic infection.

Original languageEnglish (US)
Pages (from-to)517-524
Number of pages8
JournalJournal of pediatric gastroenterology and nutrition
Volume6
Issue number4
DOIs
StatePublished - Jan 1 1987

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Acquired Immunodeficiency Syndrome
Gastrointestinal Diseases
Atrophy
Diarrhea
Biopsy
Cholecystitis
Gastrointestinal Hemorrhage
Opportunistic Infections
Klebsiella pneumoniae
Celiac Disease
Cytomegalovirus
Coinfection
Bacterial Infections
Malnutrition
Bacillus
Abdominal Pain
Weight Loss
Mucous Membrane
Macrophages
Newborn Infant

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Gastroenterology

Keywords

  • Acquired immunodeficiency syndrome
  • Enteropathy
  • Mucosal immunity
  • Opportunistic infection
  • Pseudomembranous necrotizing jejunitis
  • Serratiu mar-cescens cholecystitis
  • Villus atrophy

Cite this

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abstract = "Five children with the acquired immunodeficiency syndrome (AIDS) and unusual gastrointestinal disease are described. Two children presented with malnutrition, abdominal distention, and diarrhea. One was found to have moderately severe villus atrophy on jejunal biopsy and was initially thought to have celiac disease. Jejunal biopsy from the second child revealed infiltration of the mucosa with acid-fast bacilli-laden macrophages. A third child suffered recurrent abdominal pain, progressive weight loss, diarrhea, and severe gastrointestinal hemorrhage secondary to infection with cytomegalovirus. Pseudomembranous necrotizing jejunitis associated with overgrowth of Klebsiella pneumoniae in the duodenal fluid occurred in one patient. The fifth child presented in the newborn period with Serratiu marces-cens cholecystitis. Gastrointestinal disease in children with AIDS may be due to idiopathic villus atrophy and bacterial or opportunistic infection.",
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Severe gastrointestinal involvement in children with the acquired immunodeficiency syndrome. / McLoughlin, Lucille C.; Nord, Kenneth S.; Joshi, Vijay V.; Oleske, James.

In: Journal of pediatric gastroenterology and nutrition, Vol. 6, No. 4, 01.01.1987, p. 517-524.

Research output: Contribution to journalArticle

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AB - Five children with the acquired immunodeficiency syndrome (AIDS) and unusual gastrointestinal disease are described. Two children presented with malnutrition, abdominal distention, and diarrhea. One was found to have moderately severe villus atrophy on jejunal biopsy and was initially thought to have celiac disease. Jejunal biopsy from the second child revealed infiltration of the mucosa with acid-fast bacilli-laden macrophages. A third child suffered recurrent abdominal pain, progressive weight loss, diarrhea, and severe gastrointestinal hemorrhage secondary to infection with cytomegalovirus. Pseudomembranous necrotizing jejunitis associated with overgrowth of Klebsiella pneumoniae in the duodenal fluid occurred in one patient. The fifth child presented in the newborn period with Serratiu marces-cens cholecystitis. Gastrointestinal disease in children with AIDS may be due to idiopathic villus atrophy and bacterial or opportunistic infection.

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