Short-term regulation of organic anion transporters

Peng Duan, Guofeng You

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Organic anion transporters (OATs), which belong to the superfamily SLC22A, are key determinants in the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, and, therefore, are critical for the survival of mammalian species. Alteration in the function of these drug transporters plays important roles in intra- and inter-individual variability of the therapeutic efficacy and the toxicity of many drugs. As a result, the activity of OATs must be under tight regulation so as to carry out their normal functions. This review article highlights the recent advances from our laboratory as well as from others in delineating the short-term regulation of OATs. These advances provide important insights into strategies to maximize therapeutic efficacy in drug development.

Original languageEnglish (US)
Pages (from-to)55-61
Number of pages7
JournalPharmacology and Therapeutics
Volume125
Issue number1
DOIs
StatePublished - Jan 1 2010

Fingerprint

Organic Anion Transporters
Pharmaceutical Preparations
Drug-Related Side Effects and Adverse Reactions
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

Keywords

  • Drug transport
  • Organic anion transporters
  • Regulation

Cite this

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abstract = "Organic anion transporters (OATs), which belong to the superfamily SLC22A, are key determinants in the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, and, therefore, are critical for the survival of mammalian species. Alteration in the function of these drug transporters plays important roles in intra- and inter-individual variability of the therapeutic efficacy and the toxicity of many drugs. As a result, the activity of OATs must be under tight regulation so as to carry out their normal functions. This review article highlights the recent advances from our laboratory as well as from others in delineating the short-term regulation of OATs. These advances provide important insights into strategies to maximize therapeutic efficacy in drug development.",
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Short-term regulation of organic anion transporters. / Duan, Peng; You, Guofeng.

In: Pharmacology and Therapeutics, Vol. 125, No. 1, 01.01.2010, p. 55-61.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Short-term regulation of organic anion transporters

AU - Duan, Peng

AU - You, Guofeng

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Organic anion transporters (OATs), which belong to the superfamily SLC22A, are key determinants in the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, and, therefore, are critical for the survival of mammalian species. Alteration in the function of these drug transporters plays important roles in intra- and inter-individual variability of the therapeutic efficacy and the toxicity of many drugs. As a result, the activity of OATs must be under tight regulation so as to carry out their normal functions. This review article highlights the recent advances from our laboratory as well as from others in delineating the short-term regulation of OATs. These advances provide important insights into strategies to maximize therapeutic efficacy in drug development.

AB - Organic anion transporters (OATs), which belong to the superfamily SLC22A, are key determinants in the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, and, therefore, are critical for the survival of mammalian species. Alteration in the function of these drug transporters plays important roles in intra- and inter-individual variability of the therapeutic efficacy and the toxicity of many drugs. As a result, the activity of OATs must be under tight regulation so as to carry out their normal functions. This review article highlights the recent advances from our laboratory as well as from others in delineating the short-term regulation of OATs. These advances provide important insights into strategies to maximize therapeutic efficacy in drug development.

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KW - Organic anion transporters

KW - Regulation

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U2 - 10.1016/j.pharmthera.2009.08.002

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