Shortcut to mycothiol analogues

Spencer Knapp; Silvia Gonzalez; David S. Myers; Lisa L. Eckman; Carole A. Bewley

doi:10.1021/ol0269796

Shortcut to mycothiol analogues

Spencer Knapp, Silvia Gonzalez, David S. Myers, Lisa L. Eckman, Carole A. Bewley

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43 Scopus citations

Abstract

(equation presented) The synthesis of a simplified thioglycosidic analogue (2) of mycothiol (1) is described. Evaluation of 2 against mycothiol S-conjugate amidase from Mycobacterium tuberculosis reveals good specific activity (7500 nmol min^-1 mg-protein^-1, vs 14 200 for 1), indicating that 2 can serve as a starting point for antitubercular drug design.

Original language	English (US)
Pages (from-to)	4337-4339
Number of pages	3
Journal	Organic letters
Volume	4
Issue number	24
DOIs	https://doi.org/10.1021/ol0269796
State	Published - Nov 28 2002

All Science Journal Classification (ASJC) codes

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol0269796

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title = "Shortcut to mycothiol analogues",

abstract = "(equation presented) The synthesis of a simplified thioglycosidic analogue (2) of mycothiol (1) is described. Evaluation of 2 against mycothiol S-conjugate amidase from Mycobacterium tuberculosis reveals good specific activity (7500 nmol min-1 mg-protein-1, vs 14 200 for 1), indicating that 2 can serve as a starting point for antitubercular drug design.",

author = "Spencer Knapp and Silvia Gonzalez and Myers, {David S.} and Eckman, {Lisa L.} and Bewley, {Carole A.}",

year = "2002",

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doi = "10.1021/ol0269796",

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journal = "Organic Letters",

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T1 - Shortcut to mycothiol analogues

AU - Knapp, Spencer

AU - Gonzalez, Silvia

AU - Myers, David S.

AU - Eckman, Lisa L.

AU - Bewley, Carole A.

PY - 2002/11/28

Y1 - 2002/11/28

N2 - (equation presented) The synthesis of a simplified thioglycosidic analogue (2) of mycothiol (1) is described. Evaluation of 2 against mycothiol S-conjugate amidase from Mycobacterium tuberculosis reveals good specific activity (7500 nmol min-1 mg-protein-1, vs 14 200 for 1), indicating that 2 can serve as a starting point for antitubercular drug design.

AB - (equation presented) The synthesis of a simplified thioglycosidic analogue (2) of mycothiol (1) is described. Evaluation of 2 against mycothiol S-conjugate amidase from Mycobacterium tuberculosis reveals good specific activity (7500 nmol min-1 mg-protein-1, vs 14 200 for 1), indicating that 2 can serve as a starting point for antitubercular drug design.

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JO - Organic Letters

JF - Organic Letters

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Shortcut to mycothiol analogues

Abstract

All Science Journal Classification (ASJC) codes

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