Shortcut to mycothiol analogues

Spencer Knapp, Silvia Gonzalez, David S. Myers, Lisa L. Eckman, Carole A. Bewley

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

(equation presented) The synthesis of a simplified thioglycosidic analogue (2) of mycothiol (1) is described. Evaluation of 2 against mycothiol S-conjugate amidase from Mycobacterium tuberculosis reveals good specific activity (7500 nmol min-1 mg-protein-1, vs 14 200 for 1), indicating that 2 can serve as a starting point for antitubercular drug design.

Original languageEnglish (US)
Pages (from-to)4337-4339
Number of pages3
JournalOrganic letters
Volume4
Issue number24
DOIs
StatePublished - Nov 28 2002

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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