## Abstract

An emerging notion in systems biology is that biological networks have evolved to function well while their components behave stochastically. Thus, the dynamics in a biological network consist of two parts, deterministic and stochastic. A fundamental question is to find a quantitative relation between the two parts. We term such a relation as a deterministic-stochastic principle (DSP) and propose a model for a DSP with regard to signal propagation in biological networks. In this model, (i) the dynamics in a biological network is supposed to be captured by a stochastic differential equation which has been a standard approach in modeling systems with internal noise; (ii) the internal noise of a biological network is weak as is apparent in experimental observations; and (iii) a biological network is organized as small-world as suggested by recent studies. We introduce the concept of a signaling sample path. Using this concept we relate the structure of a biological network to its dynamics. The network structure characterizes the deterministic part of the dynamics, which in turn ensures a probability for a signal to propagate. The weakness of the internal noise characterizes the stochastic part of the dynamics. Analysis of the proposed model yields a quantitative description as follows: In a small-world biological network with weak internal noise, the signaling pathways (induced by the network structure) for a signal may ensure a probability near 0 for the signal propagation. Despite such a small probability, a correct response to the signal will still occur with a probability close to 1 provided that this signal propagation can take a certain amount of time. Computer simulations are performed to illustrate this result. We also discuss how a recent study on the reconstruction of a transcription network in Saccharomyces cerevisiae has tested the proposed model against real data.

Original language | English (US) |
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Pages (from-to) | 370-380 |

Number of pages | 11 |

Journal | Journal of Theoretical Biology |

Volume | 262 |

Issue number | 2 |

DOIs | |

State | Published - Jan 21 2010 |

## All Science Journal Classification (ASJC) codes

- Statistics and Probability
- Modeling and Simulation
- Biochemistry, Genetics and Molecular Biology(all)
- Immunology and Microbiology(all)
- Agricultural and Biological Sciences(all)
- Applied Mathematics

## Keywords

- Measure concentration
- Signal propagation
- Small-world network
- Stochastic differential equation
- Weak internal noise