Signals for pre-mRNA cleavage and polyadenylation

Bin Tian, Joel H. Graber

Research output: Contribution to journalReview articlepeer-review

149 Scopus citations


Pre-mRNA cleavage and polyadenylation is an essential step for 3' end formation of almost all protein-coding transcripts in eukaryotes. The reaction, involving cleavage of nascent mRNA followed by addition of a polyadenylate or poly(A) tail, is controlled by cis-acting elements in the pre-mRNA surrounding the cleavage site. Experimental and bioinformatic studies in the past three decades have elucidated conserved and divergent elements across eukaryotes, from yeast to human. Here we review histories and current models of these elements in a broad range of species.

Original languageEnglish (US)
Pages (from-to)385-396
Number of pages12
JournalWiley Interdisciplinary Reviews: RNA
Issue number3
StatePublished - May 2012

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology


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