Simple fast noninvasive technique for measuring brachial wall mechanics during flow mediated vasodilatation analysis

Ahmed M. Mahmoud, Phoebe A. Stapleton, Jefferson C. Frisbee, Alexandre D'Audiffret, Osama M. Mukdadi

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Measurement of flow-mediated vasodilatation (FMD) in brachial and other conduit arteries has become a common method to asses the status of endothelial function in vivo. In spite of the direct relationship between the arterial wall multi-component strains and FMD responses, direct measurement of wall strain tensor due to FMD has not yet been reported in the literature. In this work, a noninvasive direct ultrasound-based strain tensor measuring (STM) technique is presented to assess changes in the mechanical parameters of the vascular wall during FMD. The STM technique utilizes only sequences of B-mode ultrasound images, and starts with segmenting a region of interest within the artery and providing the acquisition parameters. Then a block matching technique is employed to measure the frame to frame local velocities. Displacements, diameter change, multi-component strain tensor and strain rates are then calculated by integrating or differentiating velocity components. The accuracy of the STM algorithm was assessed using a phantom study, and was further validated using in vivo data from human subjects. Results indicate the validity and versatility of the STM algorithm, and describe how parameters other than the diameter change are sensitive to pre- and post-occlusion, which can then be used for accurate assessment of atherosclerosis.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2009
Subtitle of host publicationUltrasonic Imaging and Signal Processing
StatePublished - 2009
Externally publishedYes
EventMedical Imaging 2009: Ultrasonic Imaging and Signal Processing - Lake Buena Vista, FL, United States
Duration: Feb 8 2009Feb 9 2009

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherMedical Imaging 2009: Ultrasonic Imaging and Signal Processing
Country/TerritoryUnited States
CityLake Buena Vista, FL

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging


  • Atherosclerosis
  • Flow mediated vasodilatation
  • Strain tensor measurement
  • Vascular wall mechanics


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