Simple fast noninvasive technique for measuring brachial wall mechanics during flow mediated vasodilatation analysis

Ahmed M. Mahmoud, Phoebe A. Stapleton, Jefferson C. Frisbee, Alexandre D'Audiffret, Osama M. Mukdadi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Measurement of flow-mediated vasodilatation (FMD) in brachial and other conduit arteries has become a common method to asses the status of endothelial function in vivo. In spite of the direct relationship between the arterial wall multi-component strains and FMD responses, direct measurement of wall strain tensor due to FMD has not yet been reported in the literature. In this work, a noninvasive direct ultrasound-based strain tensor measuring (STM) technique is presented to assess changes in the mechanical parameters of the vascular wall during FMD. The STM technique utilizes only sequences of B-mode ultrasound images, and starts with segmenting a region of interest within the artery and providing the acquisition parameters. Then a block matching technique is employed to measure the frame to frame local velocities. Displacements, diameter change, multi-component strain tensor and strain rates are then calculated by integrating or differentiating velocity components. The accuracy of the STM algorithm was assessed using a phantom study, and was further validated using in vivo data from human subjects. Results indicate the validity and versatility of the STM algorithm, and describe how parameters other than the diameter change are sensitive to pre- and post-occlusion, which can then be used for accurate assessment of atherosclerosis.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2009
Subtitle of host publicationUltrasonic Imaging and Signal Processing
DOIs
StatePublished - Jun 19 2009
EventMedical Imaging 2009: Ultrasonic Imaging and Signal Processing - Lake Buena Vista, FL, United States
Duration: Feb 8 2009Feb 9 2009

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7265
ISSN (Print)1605-7422

Other

OtherMedical Imaging 2009: Ultrasonic Imaging and Signal Processing
CountryUnited States
CityLake Buena Vista, FL
Period2/8/092/9/09

Fingerprint

Mechanics
Vasodilation
Arm
Tensors
tensors
Arteries
occlusion
arteries
Equidae
Reproducibility of Results
Blood Vessels
wall flow
arteriosclerosis
Ultrasonics
Atherosclerosis
Wall flow
versatility
strain rate
acquisition
Strain rate

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Keywords

  • Atherosclerosis
  • Flow mediated vasodilatation
  • Strain tensor measurement
  • Vascular wall mechanics

Cite this

Mahmoud, A. M., Stapleton, P. A., Frisbee, J. C., D'Audiffret, A., & Mukdadi, O. M. (2009). Simple fast noninvasive technique for measuring brachial wall mechanics during flow mediated vasodilatation analysis. In Medical Imaging 2009: Ultrasonic Imaging and Signal Processing [72650T] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7265). https://doi.org/10.1117/12.811634
Mahmoud, Ahmed M. ; Stapleton, Phoebe A. ; Frisbee, Jefferson C. ; D'Audiffret, Alexandre ; Mukdadi, Osama M. / Simple fast noninvasive technique for measuring brachial wall mechanics during flow mediated vasodilatation analysis. Medical Imaging 2009: Ultrasonic Imaging and Signal Processing. 2009. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).
@inproceedings{7431fa867db54220bb2261840ce129d2,
title = "Simple fast noninvasive technique for measuring brachial wall mechanics during flow mediated vasodilatation analysis",
abstract = "Measurement of flow-mediated vasodilatation (FMD) in brachial and other conduit arteries has become a common method to asses the status of endothelial function in vivo. In spite of the direct relationship between the arterial wall multi-component strains and FMD responses, direct measurement of wall strain tensor due to FMD has not yet been reported in the literature. In this work, a noninvasive direct ultrasound-based strain tensor measuring (STM) technique is presented to assess changes in the mechanical parameters of the vascular wall during FMD. The STM technique utilizes only sequences of B-mode ultrasound images, and starts with segmenting a region of interest within the artery and providing the acquisition parameters. Then a block matching technique is employed to measure the frame to frame local velocities. Displacements, diameter change, multi-component strain tensor and strain rates are then calculated by integrating or differentiating velocity components. The accuracy of the STM algorithm was assessed using a phantom study, and was further validated using in vivo data from human subjects. Results indicate the validity and versatility of the STM algorithm, and describe how parameters other than the diameter change are sensitive to pre- and post-occlusion, which can then be used for accurate assessment of atherosclerosis.",
keywords = "Atherosclerosis, Flow mediated vasodilatation, Strain tensor measurement, Vascular wall mechanics",
author = "Mahmoud, {Ahmed M.} and Stapleton, {Phoebe A.} and Frisbee, {Jefferson C.} and Alexandre D'Audiffret and Mukdadi, {Osama M.}",
year = "2009",
month = "6",
day = "19",
doi = "10.1117/12.811634",
language = "English (US)",
isbn = "9780819475169",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Medical Imaging 2009",

}

Mahmoud, AM, Stapleton, PA, Frisbee, JC, D'Audiffret, A & Mukdadi, OM 2009, Simple fast noninvasive technique for measuring brachial wall mechanics during flow mediated vasodilatation analysis. in Medical Imaging 2009: Ultrasonic Imaging and Signal Processing., 72650T, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 7265, Medical Imaging 2009: Ultrasonic Imaging and Signal Processing, Lake Buena Vista, FL, United States, 2/8/09. https://doi.org/10.1117/12.811634

Simple fast noninvasive technique for measuring brachial wall mechanics during flow mediated vasodilatation analysis. / Mahmoud, Ahmed M.; Stapleton, Phoebe A.; Frisbee, Jefferson C.; D'Audiffret, Alexandre; Mukdadi, Osama M.

Medical Imaging 2009: Ultrasonic Imaging and Signal Processing. 2009. 72650T (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7265).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

TY - GEN

T1 - Simple fast noninvasive technique for measuring brachial wall mechanics during flow mediated vasodilatation analysis

AU - Mahmoud, Ahmed M.

AU - Stapleton, Phoebe A.

AU - Frisbee, Jefferson C.

AU - D'Audiffret, Alexandre

AU - Mukdadi, Osama M.

PY - 2009/6/19

Y1 - 2009/6/19

N2 - Measurement of flow-mediated vasodilatation (FMD) in brachial and other conduit arteries has become a common method to asses the status of endothelial function in vivo. In spite of the direct relationship between the arterial wall multi-component strains and FMD responses, direct measurement of wall strain tensor due to FMD has not yet been reported in the literature. In this work, a noninvasive direct ultrasound-based strain tensor measuring (STM) technique is presented to assess changes in the mechanical parameters of the vascular wall during FMD. The STM technique utilizes only sequences of B-mode ultrasound images, and starts with segmenting a region of interest within the artery and providing the acquisition parameters. Then a block matching technique is employed to measure the frame to frame local velocities. Displacements, diameter change, multi-component strain tensor and strain rates are then calculated by integrating or differentiating velocity components. The accuracy of the STM algorithm was assessed using a phantom study, and was further validated using in vivo data from human subjects. Results indicate the validity and versatility of the STM algorithm, and describe how parameters other than the diameter change are sensitive to pre- and post-occlusion, which can then be used for accurate assessment of atherosclerosis.

AB - Measurement of flow-mediated vasodilatation (FMD) in brachial and other conduit arteries has become a common method to asses the status of endothelial function in vivo. In spite of the direct relationship between the arterial wall multi-component strains and FMD responses, direct measurement of wall strain tensor due to FMD has not yet been reported in the literature. In this work, a noninvasive direct ultrasound-based strain tensor measuring (STM) technique is presented to assess changes in the mechanical parameters of the vascular wall during FMD. The STM technique utilizes only sequences of B-mode ultrasound images, and starts with segmenting a region of interest within the artery and providing the acquisition parameters. Then a block matching technique is employed to measure the frame to frame local velocities. Displacements, diameter change, multi-component strain tensor and strain rates are then calculated by integrating or differentiating velocity components. The accuracy of the STM algorithm was assessed using a phantom study, and was further validated using in vivo data from human subjects. Results indicate the validity and versatility of the STM algorithm, and describe how parameters other than the diameter change are sensitive to pre- and post-occlusion, which can then be used for accurate assessment of atherosclerosis.

KW - Atherosclerosis

KW - Flow mediated vasodilatation

KW - Strain tensor measurement

KW - Vascular wall mechanics

UR - http://www.scopus.com/inward/record.url?scp=67149104191&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67149104191&partnerID=8YFLogxK

U2 - 10.1117/12.811634

DO - 10.1117/12.811634

M3 - Conference contribution

AN - SCOPUS:67149104191

SN - 9780819475169

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Medical Imaging 2009

ER -

Mahmoud AM, Stapleton PA, Frisbee JC, D'Audiffret A, Mukdadi OM. Simple fast noninvasive technique for measuring brachial wall mechanics during flow mediated vasodilatation analysis. In Medical Imaging 2009: Ultrasonic Imaging and Signal Processing. 2009. 72650T. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). https://doi.org/10.1117/12.811634