Sinonasal fibrosarcoma: Analysis of the Surveillance, Epidemiology, and End Results database

Tapan D. Patel, Eric T. Carniol, Alejandro Vázquez, Soly Baredes, James Liu, Jean Eloy

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Primary fibrosarcoma of the sinonasal region is an infrequently occurring malignant neoplasm. Fibrosarcomas are most commonly found in the extremities, with only 1% of fibrosarcomas reported in the head and neck region. This study analyzes the demographic, clinicopathologic, and survival characteristics of sinonasal fibrosarcoma (SNFS). Methods: The Surveillance, Epidemiology, and End Results (SEER) database (1973 to 2012) was queried for SNFS cases. Data were analyzed with respect to various demographic and clinicopathologic factors. Survival was analyzed using the Kaplan-Meier model. Results: Fifty-one cases of fibrosarcoma were identified in the sinonasal region. The mean age at diagnosis was 54.5 years and the mean survival was 119.7 months. There was no gender predilection with a male-to-female ratio of 1.04:1. The maxillary sinus was the most common site of involvement (54.9%), followed by the nasal cavity (23.5%). Five-year survival analysis revealed an overall survival rate of 71.7%, disease-specific survival rate of 77.8%, and relative survival (RS) rate of 78.8%. Disease-specific survival was better among those treated with surgery (with [76.2%] or without [87.5%] adjuvant radiotherapy) than those treated with primary radiotherapy alone (33.3%) (p = 0.0069). Conclusion: SNFS is a rare entity. This study represents the largest series of SNFS to date. The mainstay of treatment for this tumor is surgical resection with or without radiotherapy.

Original languageEnglish (US)
Pages (from-to)201-205
Number of pages5
JournalInternational Forum of Allergy and Rhinology
Volume6
Issue number2
DOIs
StatePublished - Feb 1 2016

Fingerprint

Fibrosarcoma
Epidemiology
Databases
Survival Rate
Survival Analysis
Radiotherapy
Demography
Adjuvant Radiotherapy
Maxillary Sinus
Nasal Cavity
Neoplasms
Neck
Extremities
Head

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Otorhinolaryngology

Keywords

  • Disease-specific survival
  • Fibrosarcoma
  • Malignant mesenchymal tumor
  • Nasal cancer
  • Overall survival
  • Paranasal sinus neoplasm
  • SEER
  • Sarcoma
  • Sinonasal cancer
  • Soft-tissue tumor

Cite this

Patel, Tapan D. ; Carniol, Eric T. ; Vázquez, Alejandro ; Baredes, Soly ; Liu, James ; Eloy, Jean. / Sinonasal fibrosarcoma : Analysis of the Surveillance, Epidemiology, and End Results database. In: International Forum of Allergy and Rhinology. 2016 ; Vol. 6, No. 2. pp. 201-205.
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title = "Sinonasal fibrosarcoma: Analysis of the Surveillance, Epidemiology, and End Results database",
abstract = "Background: Primary fibrosarcoma of the sinonasal region is an infrequently occurring malignant neoplasm. Fibrosarcomas are most commonly found in the extremities, with only 1{\%} of fibrosarcomas reported in the head and neck region. This study analyzes the demographic, clinicopathologic, and survival characteristics of sinonasal fibrosarcoma (SNFS). Methods: The Surveillance, Epidemiology, and End Results (SEER) database (1973 to 2012) was queried for SNFS cases. Data were analyzed with respect to various demographic and clinicopathologic factors. Survival was analyzed using the Kaplan-Meier model. Results: Fifty-one cases of fibrosarcoma were identified in the sinonasal region. The mean age at diagnosis was 54.5 years and the mean survival was 119.7 months. There was no gender predilection with a male-to-female ratio of 1.04:1. The maxillary sinus was the most common site of involvement (54.9{\%}), followed by the nasal cavity (23.5{\%}). Five-year survival analysis revealed an overall survival rate of 71.7{\%}, disease-specific survival rate of 77.8{\%}, and relative survival (RS) rate of 78.8{\%}. Disease-specific survival was better among those treated with surgery (with [76.2{\%}] or without [87.5{\%}] adjuvant radiotherapy) than those treated with primary radiotherapy alone (33.3{\%}) (p = 0.0069). Conclusion: SNFS is a rare entity. This study represents the largest series of SNFS to date. The mainstay of treatment for this tumor is surgical resection with or without radiotherapy.",
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Sinonasal fibrosarcoma : Analysis of the Surveillance, Epidemiology, and End Results database. / Patel, Tapan D.; Carniol, Eric T.; Vázquez, Alejandro; Baredes, Soly; Liu, James; Eloy, Jean.

In: International Forum of Allergy and Rhinology, Vol. 6, No. 2, 01.02.2016, p. 201-205.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Sinonasal fibrosarcoma

T2 - Analysis of the Surveillance, Epidemiology, and End Results database

AU - Patel, Tapan D.

AU - Carniol, Eric T.

AU - Vázquez, Alejandro

AU - Baredes, Soly

AU - Liu, James

AU - Eloy, Jean

PY - 2016/2/1

Y1 - 2016/2/1

N2 - Background: Primary fibrosarcoma of the sinonasal region is an infrequently occurring malignant neoplasm. Fibrosarcomas are most commonly found in the extremities, with only 1% of fibrosarcomas reported in the head and neck region. This study analyzes the demographic, clinicopathologic, and survival characteristics of sinonasal fibrosarcoma (SNFS). Methods: The Surveillance, Epidemiology, and End Results (SEER) database (1973 to 2012) was queried for SNFS cases. Data were analyzed with respect to various demographic and clinicopathologic factors. Survival was analyzed using the Kaplan-Meier model. Results: Fifty-one cases of fibrosarcoma were identified in the sinonasal region. The mean age at diagnosis was 54.5 years and the mean survival was 119.7 months. There was no gender predilection with a male-to-female ratio of 1.04:1. The maxillary sinus was the most common site of involvement (54.9%), followed by the nasal cavity (23.5%). Five-year survival analysis revealed an overall survival rate of 71.7%, disease-specific survival rate of 77.8%, and relative survival (RS) rate of 78.8%. Disease-specific survival was better among those treated with surgery (with [76.2%] or without [87.5%] adjuvant radiotherapy) than those treated with primary radiotherapy alone (33.3%) (p = 0.0069). Conclusion: SNFS is a rare entity. This study represents the largest series of SNFS to date. The mainstay of treatment for this tumor is surgical resection with or without radiotherapy.

AB - Background: Primary fibrosarcoma of the sinonasal region is an infrequently occurring malignant neoplasm. Fibrosarcomas are most commonly found in the extremities, with only 1% of fibrosarcomas reported in the head and neck region. This study analyzes the demographic, clinicopathologic, and survival characteristics of sinonasal fibrosarcoma (SNFS). Methods: The Surveillance, Epidemiology, and End Results (SEER) database (1973 to 2012) was queried for SNFS cases. Data were analyzed with respect to various demographic and clinicopathologic factors. Survival was analyzed using the Kaplan-Meier model. Results: Fifty-one cases of fibrosarcoma were identified in the sinonasal region. The mean age at diagnosis was 54.5 years and the mean survival was 119.7 months. There was no gender predilection with a male-to-female ratio of 1.04:1. The maxillary sinus was the most common site of involvement (54.9%), followed by the nasal cavity (23.5%). Five-year survival analysis revealed an overall survival rate of 71.7%, disease-specific survival rate of 77.8%, and relative survival (RS) rate of 78.8%. Disease-specific survival was better among those treated with surgery (with [76.2%] or without [87.5%] adjuvant radiotherapy) than those treated with primary radiotherapy alone (33.3%) (p = 0.0069). Conclusion: SNFS is a rare entity. This study represents the largest series of SNFS to date. The mainstay of treatment for this tumor is surgical resection with or without radiotherapy.

KW - Disease-specific survival

KW - Fibrosarcoma

KW - Malignant mesenchymal tumor

KW - Nasal cancer

KW - Overall survival

KW - Paranasal sinus neoplasm

KW - SEER

KW - Sarcoma

KW - Sinonasal cancer

KW - Soft-tissue tumor

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