SIP30 is regulated by ERK in peripheral nerve injury-induced neuropathic pain

Guangdun Peng, Mei Han, Yimin Du, Anning Lin, Lei Yu, Yuqiu Zhang, Naihe Jing

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


ERK plays an important role in chronic neuropathic pain. However, the underlying mechanism is largely unknown. Here we show that in chronic constriction injury-treated rat spinal cords, up-regulation of SIP30 (SNAP25-interacting protein 30), which is involved in the development and maintenance of chronic constriction injury-induced neuropathic pain, correlates with ERK activation and that the up-regulation of SIP30 is suppressed by intrathecal delivery of the MEK inhibitor U0126. In PC12 cells, up-regulation of SIP30 by nerve growth factor is also dependent on ERK activation. We found that there is an ERK-responsive region in the rat sip30 promoter. Activation of ERK promotes the recruitment of the transcription factor cyclic AMP-response element-binding protein to the sip30 gene promoter. Taken together, our results provide a potential downstream target of ERK activation-mediated neuropathic pain.

Original languageEnglish (US)
Pages (from-to)30138-30147
Number of pages10
JournalJournal of Biological Chemistry
Issue number44
StatePublished - Oct 30 2009

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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