TY - JOUR
T1 - SIP30 is regulated by ERK in peripheral nerve injury-induced neuropathic pain
AU - Peng, Guangdun
AU - Han, Mei
AU - Du, Yimin
AU - Lin, Anning
AU - Yu, Lei
AU - Zhang, Yuqiu
AU - Jing, Naihe
PY - 2009/10/30
Y1 - 2009/10/30
N2 - ERK plays an important role in chronic neuropathic pain. However, the underlying mechanism is largely unknown. Here we show that in chronic constriction injury-treated rat spinal cords, up-regulation of SIP30 (SNAP25-interacting protein 30), which is involved in the development and maintenance of chronic constriction injury-induced neuropathic pain, correlates with ERK activation and that the up-regulation of SIP30 is suppressed by intrathecal delivery of the MEK inhibitor U0126. In PC12 cells, up-regulation of SIP30 by nerve growth factor is also dependent on ERK activation. We found that there is an ERK-responsive region in the rat sip30 promoter. Activation of ERK promotes the recruitment of the transcription factor cyclic AMP-response element-binding protein to the sip30 gene promoter. Taken together, our results provide a potential downstream target of ERK activation-mediated neuropathic pain.
AB - ERK plays an important role in chronic neuropathic pain. However, the underlying mechanism is largely unknown. Here we show that in chronic constriction injury-treated rat spinal cords, up-regulation of SIP30 (SNAP25-interacting protein 30), which is involved in the development and maintenance of chronic constriction injury-induced neuropathic pain, correlates with ERK activation and that the up-regulation of SIP30 is suppressed by intrathecal delivery of the MEK inhibitor U0126. In PC12 cells, up-regulation of SIP30 by nerve growth factor is also dependent on ERK activation. We found that there is an ERK-responsive region in the rat sip30 promoter. Activation of ERK promotes the recruitment of the transcription factor cyclic AMP-response element-binding protein to the sip30 gene promoter. Taken together, our results provide a potential downstream target of ERK activation-mediated neuropathic pain.
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U2 - 10.1074/jbc.M109.036756
DO - 10.1074/jbc.M109.036756
M3 - Article
C2 - 19723624
AN - SCOPUS:71049138888
SN - 0021-9258
VL - 284
SP - 30138
EP - 30147
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 44
ER -