SIRT1 Is a Circadian Deacetylase for Core Clock Components

William J. Belden, Jay C. Dunlap

Research output: Contribution to journalShort surveypeer-review

90 Scopus citations


The transcriptional activator CLOCK is a histone acetyltransferase that is required for the circadian expression of many genes. Asher et al. (2008) and Nakahata et al. (2008) now demonstrate that the NAD+-dependent enzyme SIRT1 functions as a histone deacetylase that counteracts the activity of CLOCK. These results broaden our understanding of the impact of cellular metabolism on the circadian system.

Original languageEnglish (US)
Pages (from-to)212-214
Number of pages3
Issue number2
StatePublished - Jul 25 2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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