Sizing up the poly(A) tail: Insights from deep sequencing

Dinghai Zheng, Bin Tian

Research output: Contribution to journalShort surveypeer-review

14 Scopus citations

Abstract

Global investigation of poly(A) tails has been hindered by technical challenges. In a recent advance, two groups developed deep sequencing methods to globally interrogate poly(A) tail length and sequence with high precision, opening new avenues for investigation of poly(A) tail functions in mRNA metabolism. Initial applications of these methods reveal insights into the relationship between poly(A) tail length and translational efficiency, and identify widespread uridylation and guanylation at the 3' ends of transcripts.

Original languageEnglish (US)
Pages (from-to)255-257
Number of pages3
JournalTrends in Biochemical Sciences
Volume39
Issue number6
DOIs
StatePublished - Jun 2014

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

Keywords

  • MRNA stability
  • Poly(A) tail
  • Polyadenylation
  • Post-transcriptional control
  • Translation

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