Sizing up the poly(A) tail: Insights from deep sequencing

Dinghai Zheng; Bin Tian

doi:10.1016/j.tibs.2014.04.002

Sizing up the poly(A) tail: Insights from deep sequencing

Dinghai Zheng, Bin Tian

Research output: Contribution to journal › Short survey › peer-review

18 Scopus citations

Abstract

Global investigation of poly(A) tails has been hindered by technical challenges. In a recent advance, two groups developed deep sequencing methods to globally interrogate poly(A) tail length and sequence with high precision, opening new avenues for investigation of poly(A) tail functions in mRNA metabolism. Initial applications of these methods reveal insights into the relationship between poly(A) tail length and translational efficiency, and identify widespread uridylation and guanylation at the 3' ends of transcripts.

Original language	English (US)
Pages (from-to)	255-257
Number of pages	3
Journal	Trends in Biochemical Sciences
Volume	39
Issue number	6
DOIs	https://doi.org/10.1016/j.tibs.2014.04.002
State	Published - Jun 2014

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology

Keywords

MRNA stability
Poly(A) tail
Polyadenylation
Post-transcriptional control
Translation

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10.1016/j.tibs.2014.04.002

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@article{979b7c55d76047cf83ba2c0c90a99f5e,

title = "Sizing up the poly(A) tail: Insights from deep sequencing",

abstract = "Global investigation of poly(A) tails has been hindered by technical challenges. In a recent advance, two groups developed deep sequencing methods to globally interrogate poly(A) tail length and sequence with high precision, opening new avenues for investigation of poly(A) tail functions in mRNA metabolism. Initial applications of these methods reveal insights into the relationship between poly(A) tail length and translational efficiency, and identify widespread uridylation and guanylation at the 3' ends of transcripts.",

keywords = "MRNA stability, Poly(A) tail, Polyadenylation, Post-transcriptional control, Translation",

author = "Dinghai Zheng and Bin Tian",

note = "Funding Information: We thank Michael B. Mathews for helpful discussions. This work was supported by a grant from the National Institutes of Health (GM084089).",

year = "2014",

month = jun,

doi = "10.1016/j.tibs.2014.04.002",

language = "English (US)",

volume = "39",

pages = "255--257",

journal = "Trends in Biochemical Sciences",

issn = "0376-5067",

publisher = "Elsevier Limited",

number = "6",

}

TY - JOUR

T1 - Sizing up the poly(A) tail

T2 - Insights from deep sequencing

AU - Zheng, Dinghai

AU - Tian, Bin

N1 - Funding Information: We thank Michael B. Mathews for helpful discussions. This work was supported by a grant from the National Institutes of Health (GM084089).

PY - 2014/6

Y1 - 2014/6

N2 - Global investigation of poly(A) tails has been hindered by technical challenges. In a recent advance, two groups developed deep sequencing methods to globally interrogate poly(A) tail length and sequence with high precision, opening new avenues for investigation of poly(A) tail functions in mRNA metabolism. Initial applications of these methods reveal insights into the relationship between poly(A) tail length and translational efficiency, and identify widespread uridylation and guanylation at the 3' ends of transcripts.

AB - Global investigation of poly(A) tails has been hindered by technical challenges. In a recent advance, two groups developed deep sequencing methods to globally interrogate poly(A) tail length and sequence with high precision, opening new avenues for investigation of poly(A) tail functions in mRNA metabolism. Initial applications of these methods reveal insights into the relationship between poly(A) tail length and translational efficiency, and identify widespread uridylation and guanylation at the 3' ends of transcripts.

KW - MRNA stability

KW - Poly(A) tail

KW - Polyadenylation

KW - Post-transcriptional control

KW - Translation

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U2 - 10.1016/j.tibs.2014.04.002

DO - 10.1016/j.tibs.2014.04.002

M3 - Short survey

C2 - 24751511

AN - SCOPUS:84901196875

SN - 0376-5067

VL - 39

SP - 255

EP - 257

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

IS - 6

ER -

Sizing up the poly(A) tail: Insights from deep sequencing

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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