SKN7 of Candida albicans: Mutant Construction and Phenotype Analysis

Praveen Singh, Neeraj Chauhan, Anup Ghosh, Freddie Dixon, Richard Calderone

Research output: Contribution to journalArticle

81 Scopus citations

Abstract

The SKN7 two-component response regulator gene of Candida albicans was deleted, and the phenotype of the mutant was established. This mutant exhibited impaired growth on Spider agar and 10% serum agar compared to wild-type and gene-reconstituted strains. The skn7 mutant was sensitive to H20 2 in vitro, but its virulence was only mildly attenuated. A comparison of the Skn7p and Ssklp response regulators of C. albicans is discussed.

Original languageEnglish (US)
Pages (from-to)2390-2394
Number of pages5
JournalInfection and immunity
Volume72
Issue number4
DOIs
StatePublished - Apr 1 2004
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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