Sleep and benzodiazepine receptor sub-types

W. B. Mendelson, J. V. Martin, M. Perils, R. Wagner

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

CL 218,872, which preferentially binds to benzodiazepine (BZ) type 1 receptors, and flurazepam, which is thought to bind to both types 1 and 2, were given alone and in combination to rats. CL 218,872 had little effect on sleep latency, but significantly increased total sleep time. As expected, flurazepam both shortened sleep latency and prolonged total sleep. Pretreatment with CL 218,872 had no effect on these alterations in sleep induced by flurazepam. The implications for possible significance of sub-typing of BZ receptors are discussed.

Original languageEnglish (US)
Pages (from-to)329-336
Number of pages8
JournalJournal of Neural Transmission
Volume70
Issue number3-4
DOIs
StatePublished - Sep 1 1987
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

Keywords

  • CL 218,872
  • Sleep
  • benzodiazepines

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