Sleep deprivation: Neurobehavioral changes

O. Tkachenko, A. M. Spaeth, J. D. Minkel, D. F. Dinges

Research output: Chapter in Book/Report/Conference proceedingChapter


Sleep deprivation is associated with neurobehavioral deficits that include impairments in cognitive and psychomotor functions and alterations of mood. These effects appear to be due to instability of waking neurobiology resulting from sleep initiating systems when sleep drive is elevated. Attention, working memory, and divergent higher cognitive functions are particularly vulnerable to both total sleep deprivation and chronic partial sleep restriction. Few countermeasures to the neurobehavioral effects of sleep deprivation have been identified, and there is no substitute for sleep when it comes to stable wakefulness. Sleep duration is the best predictor of daily recovery of neurobehavioral functioning.

Original languageEnglish (US)
Title of host publicationThe Curated Reference Collection in Neuroscience and Biobehavioral Psychology
PublisherElsevier Science Ltd.
Number of pages8
ISBN (Electronic)9780128093245
StatePublished - Jan 1 2016
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)


  • Alertness
  • Emotion
  • Executive function
  • Microsleeps
  • Mood
  • Neurobehavioral
  • Neurocognitive
  • Performance
  • Sleep deprivation
  • Sleep restriction
  • Sleepiness
  • Working memory


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