Sleep Transcutaneous vs. End-Tidal CO 2 Monitoring for Patients with Neuromuscular Disease

Yu Hui Won, Won Ah Choi, Jang Woo Lee, John Bach, Jinyoung Park, Seong Woong Kang

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

This study compared transcutaneous carbon dioxide partial pressure (PtcCO 2 ) and end-tidal carbon dioxide partial pressure (PetCO 2 ) monitoring during sleep for patients with neuromuscular disease. Design This is a retrospective study of patients whose PtcCO 2 and PetCO 2 were monitored before they began using noninvasive mechanical ventilation. The outcomes were divided into four groupings: group 1, both PtcCO 2 and PetCO 2 are greater than or equal to 49 mm Hg; group 2, PtcCO 2 is greater than or equal to 49 mm Hg but PetCO 2 is less than 49 mm Hg; group 3, PtcCO 2 is less than 49 mm Hg but PetCO 2 is greater than or equal to 49 mm Hg; and group 4, both PtcCO 2 and PetCO 2 are less than 49 mm Hg. Results A total of 39 subjects (mean [SD] age, 27.7 [19.3] yrs) were enrolled. PtcCO 2 values were significantly higher than PetCO 2 values (P < 0.001). The intraclass correlation coefficient between maximal and mean values of PtcCO 2 and PetCO 2 was 0.612 and 0.718, respectively. Bias and limits of agreement between PtcCO 2 and PetCO 2 were-7.5 mm Hg and-21.3 to 6.3 mm Hg for maximal values and-4.8 mm Hg and-14.8 to 5.3 mm Hg for mean values. Group 2 included 19 (48.7%) and group 3 included 3 (7.6%) patients who showed discrepancy of hypercapnia between two methods. Conclusions Maximum PtcCO 2 was significantly greater than maximum PetCO 2 for both groups and, therefore, tends to be higher than PetCO 2 in this population. This should be taken into consideration when assessing patients for sleep hypoventilation.

Original languageEnglish (US)
Pages (from-to)91-95
Number of pages5
JournalAmerican Journal of Physical Medicine and Rehabilitation
Volume95
Issue number2
DOIs
StatePublished - Feb 1 2016

Fingerprint

Neuromuscular Diseases
Physiologic Monitoring
Carbon Monoxide
Sleep
Partial Pressure
Carbon Dioxide
Noninvasive Ventilation
Hypoventilation
Hypercapnia
Polysomnography
Artificial Respiration
Retrospective Studies
Population

All Science Journal Classification (ASJC) codes

  • Physical Therapy, Sports Therapy and Rehabilitation
  • Rehabilitation

Cite this

Won, Yu Hui ; Choi, Won Ah ; Lee, Jang Woo ; Bach, John ; Park, Jinyoung ; Kang, Seong Woong. / Sleep Transcutaneous vs. End-Tidal CO 2 Monitoring for Patients with Neuromuscular Disease In: American Journal of Physical Medicine and Rehabilitation. 2016 ; Vol. 95, No. 2. pp. 91-95.
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abstract = "This study compared transcutaneous carbon dioxide partial pressure (PtcCO 2 ) and end-tidal carbon dioxide partial pressure (PetCO 2 ) monitoring during sleep for patients with neuromuscular disease. Design This is a retrospective study of patients whose PtcCO 2 and PetCO 2 were monitored before they began using noninvasive mechanical ventilation. The outcomes were divided into four groupings: group 1, both PtcCO 2 and PetCO 2 are greater than or equal to 49 mm Hg; group 2, PtcCO 2 is greater than or equal to 49 mm Hg but PetCO 2 is less than 49 mm Hg; group 3, PtcCO 2 is less than 49 mm Hg but PetCO 2 is greater than or equal to 49 mm Hg; and group 4, both PtcCO 2 and PetCO 2 are less than 49 mm Hg. Results A total of 39 subjects (mean [SD] age, 27.7 [19.3] yrs) were enrolled. PtcCO 2 values were significantly higher than PetCO 2 values (P < 0.001). The intraclass correlation coefficient between maximal and mean values of PtcCO 2 and PetCO 2 was 0.612 and 0.718, respectively. Bias and limits of agreement between PtcCO 2 and PetCO 2 were-7.5 mm Hg and-21.3 to 6.3 mm Hg for maximal values and-4.8 mm Hg and-14.8 to 5.3 mm Hg for mean values. Group 2 included 19 (48.7{\%}) and group 3 included 3 (7.6{\%}) patients who showed discrepancy of hypercapnia between two methods. Conclusions Maximum PtcCO 2 was significantly greater than maximum PetCO 2 for both groups and, therefore, tends to be higher than PetCO 2 in this population. This should be taken into consideration when assessing patients for sleep hypoventilation.",
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Sleep Transcutaneous vs. End-Tidal CO 2 Monitoring for Patients with Neuromuscular Disease . / Won, Yu Hui; Choi, Won Ah; Lee, Jang Woo; Bach, John; Park, Jinyoung; Kang, Seong Woong.

In: American Journal of Physical Medicine and Rehabilitation, Vol. 95, No. 2, 01.02.2016, p. 91-95.

Research output: Contribution to journalArticle

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N2 - This study compared transcutaneous carbon dioxide partial pressure (PtcCO 2 ) and end-tidal carbon dioxide partial pressure (PetCO 2 ) monitoring during sleep for patients with neuromuscular disease. Design This is a retrospective study of patients whose PtcCO 2 and PetCO 2 were monitored before they began using noninvasive mechanical ventilation. The outcomes were divided into four groupings: group 1, both PtcCO 2 and PetCO 2 are greater than or equal to 49 mm Hg; group 2, PtcCO 2 is greater than or equal to 49 mm Hg but PetCO 2 is less than 49 mm Hg; group 3, PtcCO 2 is less than 49 mm Hg but PetCO 2 is greater than or equal to 49 mm Hg; and group 4, both PtcCO 2 and PetCO 2 are less than 49 mm Hg. Results A total of 39 subjects (mean [SD] age, 27.7 [19.3] yrs) were enrolled. PtcCO 2 values were significantly higher than PetCO 2 values (P < 0.001). The intraclass correlation coefficient between maximal and mean values of PtcCO 2 and PetCO 2 was 0.612 and 0.718, respectively. Bias and limits of agreement between PtcCO 2 and PetCO 2 were-7.5 mm Hg and-21.3 to 6.3 mm Hg for maximal values and-4.8 mm Hg and-14.8 to 5.3 mm Hg for mean values. Group 2 included 19 (48.7%) and group 3 included 3 (7.6%) patients who showed discrepancy of hypercapnia between two methods. Conclusions Maximum PtcCO 2 was significantly greater than maximum PetCO 2 for both groups and, therefore, tends to be higher than PetCO 2 in this population. This should be taken into consideration when assessing patients for sleep hypoventilation.

AB - This study compared transcutaneous carbon dioxide partial pressure (PtcCO 2 ) and end-tidal carbon dioxide partial pressure (PetCO 2 ) monitoring during sleep for patients with neuromuscular disease. Design This is a retrospective study of patients whose PtcCO 2 and PetCO 2 were monitored before they began using noninvasive mechanical ventilation. The outcomes were divided into four groupings: group 1, both PtcCO 2 and PetCO 2 are greater than or equal to 49 mm Hg; group 2, PtcCO 2 is greater than or equal to 49 mm Hg but PetCO 2 is less than 49 mm Hg; group 3, PtcCO 2 is less than 49 mm Hg but PetCO 2 is greater than or equal to 49 mm Hg; and group 4, both PtcCO 2 and PetCO 2 are less than 49 mm Hg. Results A total of 39 subjects (mean [SD] age, 27.7 [19.3] yrs) were enrolled. PtcCO 2 values were significantly higher than PetCO 2 values (P < 0.001). The intraclass correlation coefficient between maximal and mean values of PtcCO 2 and PetCO 2 was 0.612 and 0.718, respectively. Bias and limits of agreement between PtcCO 2 and PetCO 2 were-7.5 mm Hg and-21.3 to 6.3 mm Hg for maximal values and-4.8 mm Hg and-14.8 to 5.3 mm Hg for mean values. Group 2 included 19 (48.7%) and group 3 included 3 (7.6%) patients who showed discrepancy of hypercapnia between two methods. Conclusions Maximum PtcCO 2 was significantly greater than maximum PetCO 2 for both groups and, therefore, tends to be higher than PetCO 2 in this population. This should be taken into consideration when assessing patients for sleep hypoventilation.

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