Abstract
The effect of a slow-released natural antimicrobial, salicylic acid (SA), was tested onbiofilm formation in Salmonella typhimurium MAE52. Glass coverslips coated withpoly(anhydride) ester with salicylic acid built into the polymer backbone (SA-PAE) wereused to study the release of SA during polymer degradation. S. typhimurium MAE52 wasfound to follow bimodal pH kinetics when cultured in initially-neutral BHI medium (pH7.2), with the formation of biofilms occurring after 12 hours of incubation. Continuousrelease of SA from SA-PAE coverslips resulted in a disruption of the pH profile andprevention of biofilm formation. The controlled release of SA over time influencedcellular functions (i.e. metabolism), reflected in the disruption of the bimodal pH. Whilefuture research is necessary to elucidate how cellular regulation is affected duringexposure to salicylic acid, the delivery of salicylic acid through a degradable polymershows great potential in the prevention of biofilm formation.
| Original language | English (US) |
|---|---|
| Title of host publication | Biofilms |
| Subtitle of host publication | Formation, Development and Properties |
| Publisher | Nova Science Publishers, Inc. |
| Pages | 649-658 |
| Number of pages | 10 |
| ISBN (Print) | 9781617282935 |
| State | Published - 2011 |
All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
Keywords
- Antimicrobials
- Biofilms
- PH
- Poly(anhydride esters)
- Salicylic acid
- Salmonella