Small voltage changes at nerve terminals travel up axons to affect action potential initiation

Kenneth Paradiso; Ling Gang Wu

doi:10.1038/nn.2301

Small voltage changes at nerve terminals travel up axons to affect action potential initiation

Kenneth Paradiso, Ling Gang Wu

Robert Wood Johnson Medical School (RWJMS), Pediatrics-Nephrology

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Nerve terminals are generally considered to be the destination points for electrical signals, which propagate unidirectionally from the soma to nerve terminals. We found that small hyperpolarizations or depolarizations (10 mV) generated under physiological conditions in rat nerve terminals backpropagated up the axon (400-800 m) and changed the threshold for initiating action potentials and thus firing patterns. These results suggest a mechanism for information processing in neurons and neuronal circuits.

Original language	English (US)
Pages (from-to)	541-543
Number of pages	3
Journal	Nature Neuroscience
Volume	12
Issue number	5
DOIs	https://doi.org/10.1038/nn.2301
State	Published - May 2009

All Science Journal Classification (ASJC) codes

Neuroscience(all)

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10.1038/nn.2301

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title = "Small voltage changes at nerve terminals travel up axons to affect action potential initiation",

abstract = "Nerve terminals are generally considered to be the destination points for electrical signals, which propagate unidirectionally from the soma to nerve terminals. We found that small hyperpolarizations or depolarizations (10 mV) generated under physiological conditions in rat nerve terminals backpropagated up the axon (400-800 m) and changed the threshold for initiating action potentials and thus firing patterns. These results suggest a mechanism for information processing in neurons and neuronal circuits.",

author = "Kenneth Paradiso and Wu, {Ling Gang}",

note = "Funding Information: We thank J. Diamond, A. Elhamdani, B. McNeil, D. Robinson and J. Xu for insightful comments. This work was supported by the National Institute of Neurological Disorders and Stroke Intramural Program and a K22 Award to K.P. (K22NS051401).",

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N2 - Nerve terminals are generally considered to be the destination points for electrical signals, which propagate unidirectionally from the soma to nerve terminals. We found that small hyperpolarizations or depolarizations (10 mV) generated under physiological conditions in rat nerve terminals backpropagated up the axon (400-800 m) and changed the threshold for initiating action potentials and thus firing patterns. These results suggest a mechanism for information processing in neurons and neuronal circuits.

AB - Nerve terminals are generally considered to be the destination points for electrical signals, which propagate unidirectionally from the soma to nerve terminals. We found that small hyperpolarizations or depolarizations (10 mV) generated under physiological conditions in rat nerve terminals backpropagated up the axon (400-800 m) and changed the threshold for initiating action potentials and thus firing patterns. These results suggest a mechanism for information processing in neurons and neuronal circuits.

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Small voltage changes at nerve terminals travel up axons to affect action potential initiation

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