Smoking, nicotine, nicotine replacement, and cardiovascular disease

Anjum Ismail, William H. Frishman, Marc Klapholz

Research output: Contribution to journalArticlepeer-review


Cigarette smoking is a major risk factor for the development of coronary artery disease and its complications. Nicotine is one of the major substances that contributes to the pharmacologic activity of cigarette smoke, its toxicity, as well as its addictive nature. Strategies have been developed that utilize nicotine as a replacement substance in motivated patients who wish to stop smoking. Studies have shown that nicotine replacement therapy can be used safely in patients with known coronary artery disease.

Original languageEnglish (US)
Pages (from-to)348-357
Number of pages10
JournalAmerican journal of therapeutics
Issue number5
StatePublished - May 1996
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)


  • nicotine
  • nicotine replacement
  • smoking


Dive into the research topics of 'Smoking, nicotine, nicotine replacement, and cardiovascular disease'. Together they form a unique fingerprint.

Cite this